Research in motion: the enigma of Parkinson's disease pathology spread

被引：252

作者：

Brundin, Patrik ^{[1
]}

Li, Jia-Yi ^{[1
]}

Holton, Janice L. ^{[2
]}

Lindvall, Olle ^{[3
,4
]}

Revesz, Tamas ^{[2
]}

机构：

[1] Lund Univ, Wallenberg Neurosci Ctr, Neuronal Survival Unit, Dept Expt Med Sci, SE-22184 Lund, Sweden

[2] UCL, Queen Sq Brain Bank Neurol Disorders, Dept Mol Neurosci, Inst Neurol, London WC1N 3BG, England

[3] Univ Lund Hosp, Dept Clin Sci, Div Neurol, SE-22185 Lund, Sweden

[4] Lund Univ, Sect Restorat Neurol, Wallenberg Neurosci Ctr, SE-22184 Lund, Sweden

来源：

NATURE REVIEWS NEUROSCIENCE | 2008年 / 9卷 / 10期

基金：

瑞典研究理事会;

关键词：

D O I：

10.1038/nrn2477

中图分类号：

Q189 [神经科学];

学科分类号：

071006 [神经生物学];

摘要：

Neuropathological changes in Parkinson's disease progress slowly and spread according to a characteristic pattern. Recent papers have shed light on this progression of pathology by examining the fate of neurons grafted into the brains of patients with Parkinson's disease. Two of these studies demonstrate that grafted healthy neurons can gradually develop the same pathology as host neurons in the diseased brains. According to these studies, implanted neurons developed alpha-synuclein- and ubiquitin-positive Lewy bodies more than a decade after transplantation. We discuss the possible underlying mechanisms and their implications for how pathology spreads in Parkinson's disease.

引用

页码：741 / 745

页数：5

共 56 条

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