Synthesis and biological evaluation of 1 alpha-hydroxy-25(R and S)-25,26-epoxy-23-yne vitamin D-3 and of 1a,25(R and S),26-trihydroxy-23-yne vitamin D-3.

被引：6

作者：

Wu, YS ^{[1
]}

Zhao, XY ^{[1
]}

DeClercq, P ^{[1
]}

Vandewalle, M ^{[1
]}

Bouillon, R ^{[1
]}

Verstuyf, A ^{[1
]}

机构：

[1] KATHOLIEKE UNIV LEUVEN,LAB EXPT GENEESKUNDE ENDOCRINOL,ONDERWIJS & NAVORSING GASTHUISBERG,B-3030 LOUVAIN,BELGIUM

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1997年 / 7卷 / 07期

关键词：

D O I：

10.1016/S0960-894X(97)00138-8

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The synthesis of both 1 alpha-hydroxy-25(R and S)-25,26-epoxy-23-yne vitamin D-3 and of both 1 alpha,2S(R and S),26-trihydroxy-23-yne vitamin D-3 is described. Biological evaluation includes the study of calcemic effect, receptor binding and cell differentiation. (C) 1997 Published by Elsevier Science Ltd.

引用

页码：929 / 932

页数：4

共 15 条

[1] BIOLOGICAL EVALUATION OF EPOXY ANALOGS OF 1-ALPHA,25-DIHYDROXYVITAMIN-D-3 [J].