Kaposi's sarcoma-associated herpesvirus: a new human tumor virus, but how?

被引:29
作者
Schulz, TF
Moore, PS
机构
[1] Univ Liverpool, Dept Med Microbiol & Genitourinary Med, Mol Virol Grp, Liverpool L69 3GA, Merseyside, England
[2] Columbia Univ, Dept Epidemiol, New York, NY 10032 USA
关键词
D O I
10.1016/S0966-842X(99)01495-X
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Kaposi's sarcoma-associated herpesvirus, or human herpesvirus 8, the most recently discovered human tumor virus, is involved in the pathogenesis of Kaposi's sarcoma, primary effusion lymphoma and some cases of multicentric Castleman's disease. It is non-pathogenic in the majority of otherwise healthy individuals but highly oncogenic in the context of HIV-1 infection and iatrogenic immune suppression, and other cofactors might exist. Several viral genes can interfere with normal cell growth and differentiation, but their precise role in oncogenesis is still under investigation.
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收藏
页码:196 / 200
页数:5
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