Kaposi's sarcoma-associated herpesvirus: a new human tumor virus, but how?

被引：29

作者：

Schulz, TF

Moore, PS

机构：

[1] Univ Liverpool, Dept Med Microbiol & Genitourinary Med, Mol Virol Grp, Liverpool L69 3GA, Merseyside, England

[2] Columbia Univ, Dept Epidemiol, New York, NY 10032 USA

来源：

TRENDS IN MICROBIOLOGY | 1999年 / 7卷 / 05期

关键词：

D O I：

10.1016/S0966-842X(99)01495-X

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Kaposi's sarcoma-associated herpesvirus, or human herpesvirus 8, the most recently discovered human tumor virus, is involved in the pathogenesis of Kaposi's sarcoma, primary effusion lymphoma and some cases of multicentric Castleman's disease. It is non-pathogenic in the majority of otherwise healthy individuals but highly oncogenic in the context of HIV-1 infection and iatrogenic immune suppression, and other cofactors might exist. Several viral genes can interfere with normal cell growth and differentiation, but their precise role in oncogenesis is still under investigation.

引用

页码：196 / 200

页数：5

共 70 条

[1]

ARIYOSHI A, 1998, J HUMAN VIROL, V1, P193

[2] G-protein-coupled receptor of Kaposi's sarcoma-associated herpesvirus is a viral oncogene and angiogenesis activator [J].

Bais, C ;

Santomasso, B ;

Coso, O ;

Arvanitakis, L ;

Raaka, EG ;

Gutkind, JS ;

Asch, AS ;

Cesarman, E ;

Gerhengorn, MC ;

Mesri, EA .

NATURE, 1998, 391 (6662) :86-89

[3] IS RISK OF KAPOSIS-SARCOMA IN AIDS PATIENTS IN BRITAIN INCREASED IF SEXUAL PARTNERS CAME FROM UNITED-STATES OR AFRICA [J].

BERAL, V ;

BULL, D ;

JAFFE, H ;

EVANS, B ;

GILL, N ;

TILLETT, H ;

SWERDLOW, AJ .

BRITISH MEDICAL JOURNAL, 1991, 302 (6777) :624-625

[4]

Bestetti G, 1998, AIDS, V12, P541

[5] Human herpesvirus 8 in semen and prostate [J].

Blackbourn, DJ ;

Levy, JA .

AIDS, 1997, 11 (02) :249-250

[6] Human herpesvirus 8 infection occurs following adolescence in the United States [J].

Blauvelt, A ;

Sei, S ;

Cook, PM ;

Schulz, TF ;

Jeang, KT .

JOURNAL OF INFECTIOUS DISEASES, 1997, 176 (03) :771-774

[7] Angiogenic and HIV-inhibitory functions of KSHV-encoded chemokines [J].

Boshoff, C ;

Endo, Y ;

Collins, PD ;

Takeuchi, Y ;

Reeves, JD ;

Schweickart, VL ;

Siani, MA ;

Sasaki, T ;

Williams, TJ ;

Gray, PW ;

Moore, PS ;

Chang, Y ;

Weiss, RA .

SCIENCE, 1997, 278 (5336) :290-294

[8] KAPOSIS SARCOMA-ASSOCIATED HERPESVIRUS INFECTS ENDOTHELIAL AND SPINDLE CELLS [J].

BOSHOFF, C ;

SCHULZ, TF ;

KENNEDY, MM ;

GRAHAM, AK ;

FISHER, C ;

THOMAS, A ;

MCGEE, JO ;

WEISS, RA ;

OLEARY, JJ .

NATURE MEDICINE, 1995, 1 (12) :1274-1278

[9] Kaposi's sarcoma-associated herpesvirus [J].

Boshoff, C ;

Weiss, RA .

ADVANCES IN CANCER RESEARCH, VOL 75, 1998, 75 :57-86

[10] Serologic evidence for mother-to-child transmission of Kaposi sarcoma-associated herpesvirus infection [J].

Bourboulia, D ;

Whitby, D ;

Boshoff, C ;

Newton, R ;

Beral, V ;

Carrara, H ;

Lane, A ;

Sitas, F .

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 1998, 280 (01) :31-32

← 1 2 3 4 5 6 7 →