Evidence-Based Recommendations for Optimal Dietary Protein Intake in Older People: A Position Paper From the PROT-AGE Study Group

被引:1637
作者
Bauer, Juergen [1 ]
Biolo, Gianni [2 ]
Cederholm, Tommy [3 ]
Cesari, Matteo [4 ]
Cruz-Jentoft, Alfonso J. [5 ]
Morley, John E. [6 ]
Phillips, Stuart [7 ]
Sieber, Cornel [8 ]
Stehle, Peter [9 ]
Teta, Daniel [10 ]
Visvanathan, Renuka [11 ]
Volpi, Elena [12 ]
Boirie, Yves [13 ]
机构
[1] Geriatr Ctr Oldenburg, D-26133 Oldenburg, Germany
[2] Univ Trieste, Trieste, Italy
[3] Uppsala Univ, Uppsala, Sweden
[4] Univ Toulouse 3, INSERM, UMR1027, F-31062 Toulouse, France
[5] Hosp Univ Ramon y Cajal, Madrid, Spain
[6] St Louis Univ, Sch Med, St Louis, MO USA
[7] McMaster Univ, Hamilton, ON, Canada
[8] Univ Erlangen Nurnberg, Nurnberg, Germany
[9] Univ Bonn, Bonn, Germany
[10] CHU Vaudois, Serv Nephrol, CH-1011 Lausanne, Switzerland
[11] Univ Adelaide, Adelaide, SA, Australia
[12] Univ Texas Med Branch, Galveston, TX 77555 USA
[13] Univ Auvergne, INRA, CRNH, Ctr Hosp Univ, Clermont Ferrand, France
关键词
Older people; dietary protein; exercise; protein quality; physical function; OBSTRUCTIVE PULMONARY-DISEASE; AMINO-ACID-REQUIREMENTS; BETA-METHYLBUTYRATE HMB; ORAL NUTRITIONAL SUPPLEMENTS; LOWER-EXTREMITY FUNCTION; CRITICALLY-ILL PATIENTS; FRAIL ELDERLY-PEOPLE; BONE-MINERAL DENSITY; MUSCLE PROTEIN; BODY-COMPOSITION;
D O I
10.1016/j.jamda.2013.05.021
中图分类号
R592 [老年病学]; C [社会科学总论];
学科分类号
03 ; 0303 ; 100203 ;
摘要
New evidence shows that older adults need more dietary protein than do younger adults to support good health, promote recovery from illness, and maintain functionality. Older people need to make up for age-related changes in protein metabolism, such as high splanchnic extraction and declining anabolic responses to ingested protein. They also need more protein to offset inflammatory and catabolic conditions associated with chronic and acute diseases that occur commonly with aging. With the goal of developing updated, evidence-based recommendations for optimal protein intake by older people, the European Union Geriatric Medicine Society (EUGMS), in cooperation with other scientific organizations, appointed an international study group to review dietary protein needs with aging (PROT-AGE Study Group). To help older people (>65 years) maintain and regain lean body mass and function, the PROT-AGE study group recommends average daily intake at least in the range of 1.0 to 1.2 g protein per kilogram of body weight per day. Both endurance-and resistance-type exercises are recommended at individualized levels that are safe and tolerated, and higher protein intake (ie, >= 1.2 g/kg body weight/d) is advised for those who are exercising and otherwise active. Most older adults who have acute or chronic diseases need even more dietary protein (ie, 1.2-1.5 g/kg body weight/d). Older people with severe kidney disease (ie, estimated GFR <30 mL/min/1.73m(2)), but who are not on dialysis, are an exception to this rule; these individuals may need to limit protein intake. Protein quality, timing of ingestion, and intake of other nutritional supplements may be relevant, but evidence is not yet sufficient to support specific recommendations. Older people are vulnerable to losses in physical function capacity, and such losses predict loss of independence, falls, and even mortality. Thus, future studies aimed at pinpointing optimal protein intake in specific populations of older people need to include measures of physical function. Copyright (C) 2013 - American Medical Directors Association, Inc.
引用
收藏
页码:542 / 559
页数:18
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