Endoplasmic reticulum stress and the making of a professional secretory cell

被引：55

作者：

van Anken, E ^{[1
]}

Braakman, I ^{[1
]}

机构：

[1] Univ Utrecht, Bijvoet Ctr, Dept Cellular Prot Chem, NL-3584 CH Utrecht, Netherlands

来源：

CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY | 2005年 / 40卷 / 05期

关键词：

UPR; ATF6; ATF4; PERK; Ire1; XBP-1; ERAD;

D O I：

10.1080/10409230500315352

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Homeostasis of the protein folding machinery in the endoplasmic reticulum (ER) is maintained via several parallel unfolded protein response pathways that are remarkably conserved from yeast to man. Together, these pathways are integrated into a complex circuitry that can be modulated in various ways, not only to cope with various stress conditions, but also to fine-tune the capacity of the ER folding machinery when precursor cells differentiate into professional secretory cells.

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收藏

页码：269 / 283

页数：15

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