Alterations in neuropeptide Y levels and Y1 binding sites in the Flinders Sensitive Line rats, a genetic animal model of depression

被引：89

作者：

Caberlotto, L

Jimenez, P

Overstreet, DH

Hurd, YL ^{[1
]}

Mathé, AA

Fuxe, K

机构：

[1] Karolinska Hosp, Dept Clin Neurosci, Psychiat Sect, S-17176 Stockholm, Sweden

[2] Karolinska Inst, Dept Neurosci, Div Cellular & Mol Neurochem, S-17175 Stockholm, Sweden

[3] Karolinska Inst, Psychiat Sect, Dept Clin Neurosci, St Gorans Hosp, S-11281 Stockholm, Sweden

[4] Univ N Carolina, Dept Psychiat, Chapel Hill, NC 27599 USA

来源：

NEUROSCIENCE LETTERS | 1999年 / 265卷 / 03期

关键词：

neuropeptide Y; NPY receptors; depression; Flinders Sensitive Line Rats; fluoxetine; hippocampus;

D O I：

10.1016/S0304-3940(99)00234-7

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Previously, we observed specific alterations of neuropeptide Y (NPY) and Y1 receptor mRNA expression in discrete regions of the Flinders Sensitive Line rats (FSL), an animal model of depression. In order to clarify the correlation between mRNA expression and protein content, radioimmunoassay and receptor autoradiography were currently performed. In the FSL rats, NPY-like immunoreactivity (NPY-II) was decreased in the hippocampal CA region, while Y1 binding sites were increased; NPY-LI was increased in the arcuate nucleus. Fluoxetine treatment elevated NPY-LI in the arcuate and anterior cingulate cortex and increased Y1 binding sites in the medial amygdala and occipital cortex in both strains. No differences were found regarding the Y2 binding sites. The results demonstrate a good correlation between NPY peptide and mRNA expression, and sustain the possible involvement of NPY and Y1 receptors in depression. (C)1999 Elsevier Science Ireland Ltd. All rights reserved.

引用

页码：191 / 194

页数：4

共 21 条

[1] Alterations in neuropeptide Y and Y1 receptor mRNA expression in brains from an animal model of depression: region specific adaptation after fluoxetine treatment [J].