Differential sensitivities to tyrosine kinase inhibitors in NSCLC harboring EGFR mutation and ALK translocation

被引：117

作者：

Lee, June Koo ^{[1
]}

Kim, Tae Min ^{[1
]}

Koh, Youngil ^{[1
]}

Lee, Se-Hoon ^{[1
]}

Kim, Dong-Wan ^{[1
]}

Jeon, Yoon-Kyung ^{[2
]}

Chung, Doo Hyun ^{[2
]}

Yang, Seok-Chul ^{[1
]}

Kim, Young Tae ^{[3
]}

Kim, Young-Whan ^{[1
]}

Heo, Dae Seog ^{[1
]}

Bang, Yung-Jue ^{[1
]}

机构：

[1] Seoul Natl Univ, Seoul Natl Univ Hosp, Dept Internal Med, Canc Res Inst,Coll Med, Seoul 110744, South Korea

[2] Seoul Natl Univ, Seoul Natl Univ Hosp, Dept Pathol, Canc Res Inst,Coll Med, Seoul 110744, South Korea

[3] Seoul Natl Univ, Seoul Natl Univ Hosp, Dept Thorac Surg, Canc Res Inst,Coll Med, Seoul 110744, South Korea

来源：

LUNG CANCER | 2012年 / 77卷 / 02期

关键词：

Non-small cell lung cancer; EGFR mutation; ALK translocation; EML4-ALK FUSION GENE; CELL LUNG-CANCER; ADENOCARCINOMA; RESISTANCE; GEFITINIB; ADDICTION; LEADS;

D O I：

10.1016/j.lungcan.2012.04.012

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 [肿瘤学];

摘要：

Epidermal growth factor receptor (EGFR) mutations and anaplastic lymphoma kinase (ALK) translocations in non-small cell lung cancer (NSCLC) are mutually exclusive. However, several exceptional cases harboring both genetic alterations have been reported. In this study, a total of 444 patients with lung adenocarcinoma were examined for their EGFR and ALK status at Seoul National University Hospital between July 2008 and September 2011. EGFR mutations and ALK translocations were detected in 228 (51.4%) and 34 (7.7%) patients, respectively. Four patients (0.9%) had both genetic alterations and three underwent curative surgery. One patient who received both EGFR tyrosine kinase and ALK inhibitors, separately showed an objective response to the ALK inhibitor alone. Considering our and previous studies, patients harboring both EGFR mutation and ALK translocation showed differential sensitivities to both targeted therapies, suggesting a variable dependence on EGFR and ALK oncogenes. (C) 2012 Elsevier Ireland Ltd. All rights reserved.

引用

页码：460 / 463

页数：4

共 18 条

[1]

MET amplification leads to gefitinib resistance in lung cancer by activating ERBB3 signaling [J].

Engelman, Jeffrey A. ;

Zejnullahu, Kreshnik ;

Mitsudomi, Tetsuya ;

Song, Youngchul ;

Hyland, Courtney ;

Park, Joon Oh ;

Lindeman, Neal ;

Gale, Christopher-Michael ;

Zhao, Xiaojun ;

Christensen, James ;

Kosaka, Takayuki ;

Holmes, Alison J. ;

Rogers, Andrew M. ;

Cappuzzo, Federico ;

Mok, Tony ;

Lee, Charles ;

Johnson, Bruce E. ;

Cantley, Lewis C. ;

Janne, Pasi A. .

SCIENCE, 2007, 316 (5827) :1039-1043

[2]

High MET Gene Copy Number Leads to Shorter Survival in Patients with Non-small Cell Lung Cancer [J].

Go, Heounjeong ;

Jeon, Yoon Kyung ;

Park, Hyo Jin ;

Sung, Sook-Whan ;

Seo, Jeong-Wook ;

Chung, Doo Hyun .

JOURNAL OF THORACIC ONCOLOGY, 2010, 5 (03) :305-313

[3]

A rapid and sensitive enzymatic method for epidermal growth factor receptor mutation screening [J].

Jänne, PA ;

Borras, AM ;

Kuang, YN ;

Rogers, AM ;

Joshi, VA ;

Liyanage, H ;

Lindeman, N ;

Lee, JC ;

Halmos, B ;

Maher, EA ;

Distel, RJ ;

Meyerson, M ;

Johnson, BE .

CLINICAL CANCER RESEARCH, 2006, 12 (03) :751-758

[4]

Molecular changes of epidermal growth factor receptor (EGFR) and KRAS and their impact on the clinical outcomes in surgically resected adenocarcinoma of the lung [J].

Kim, Young Tae ;

Kim, Tae-you ;

Lee, Dong Soon ;

Park, Sun Jung ;

Park, Ju-Yeon ;

Seo, Soon-Jung ;

Choi, Hyo-Seon ;

Kang, Hee Jung ;

Hahn, Seokyung ;

Kang, Chang Hyun ;

Sung, Sook Whan ;

Kim, Joo Hyun .

LUNG CANCER, 2008, 59 (01) :111-118

[5]

EML4-ALK fusion gene and efficacy of an ALK kinase inhibitor in lung cancer [J].

Koivunen, Jussi P. ;

Mermel, Craig ;

Zejnullahu, Kreshnik ;

Murphy, Carly ;

Lifshits, Eugene ;

Holmes, Alison J. ;

Choi, Hwan Geun ;

Kim, Jhingook ;

Chiang, Derek ;

Thomas, Roman ;

Lee, Jinseon ;

Richards, William G. ;

Sugarbaker, David J. ;

Ducko, Christopher ;

Lindeman, Neal ;

Marcoux, J. Paul ;

Engelman, Jeffrey A. ;

Gray, Nathanael S. ;

Lee, Charles ;

Meyerson, Matthew ;

Janne, Pasi A. .

CLINICAL CANCER RESEARCH, 2008, 14 (13) :4275-4283

[6]

Good Response to Gefitinib in Lung Adenocarcinoma Harboring Coexisting EML4-ALK Fusion Gene and EGFR Mutation [J].

Kuo, Yao-Wen ;

Wu, Shang-Gin ;

Ho, Chao-Chi ;

Shih, Jin-Yuan .

JOURNAL OF THORACIC ONCOLOGY, 2010, 5 (12) :2039-2040

[7]

Anaplastic Lymphoma Kinase Inhibition in Non-Small-Cell Lung Cancer [J].

Kwak, Eunice L. ;

Bang, Yung-Jue ;

Camidge, D. Ross ;

Shaw, Alice T. ;

Solomon, Benjamin ;

Maki, Robert G. ;

Ou, Sai-Hong I. ;

Dezube, Bruce J. ;

Jaenne, Pasi A. ;

Costa, Daniel B. ;

Varella-Garcia, Marileila ;

Kim, Woo-Ho ;

Lynch, Thomas J. ;

Fidias, Panos ;

Stubbs, Hannah ;

Engelman, Jeffrey A. ;

Sequist, Lecia V. ;

Tan, WeiWei ;

Gandhi, Leena ;

Mino-Kenudson, Mari ;

Wei, Greg C. ;

Shreeve, S. Martin ;

Ratain, Mark J. ;

Settleman, Jeffrey ;

Christensen, James G. ;

Haber, Daniel A. ;

Wilner, Keith ;

Salgia, Ravi ;

Shapiro, Geoffrey I. ;

Clark, Jeffrey W. ;

Iafrate, A. John .

NEW ENGLAND JOURNAL OF MEDICINE, 2010, 363 (18) :1693-1703

[8]

Assessment of somatic k-RAS mutations as a mechanism associated with resistance to EGFR-targeted agents:: a systematic review and meta-analysis of studies in advanced non-small-cell lung cancer and metastatic colorectal cancer [J].

Linardou, Helena ;

Dahabreh, Issa J. ;

Kanaloupiti, Dimitra ;

Siannis, Fotios ;

Bafaloukos, Dimitrios ;

Kosmidis, Paris ;

Papadimitriou, Christos A. ;

Murray, Samuel .

LANCET ONCOLOGY, 2008, 9 (10) :962-972

[9]

Activating mutations in the epidermal growth factor receptor underlying responsiveness of non-small-cell lung cancer to gefitinib [J].

Lynch, TJ ;

Bell, DW ;

Sordella, R ;

Gurubhagavatula, S ;

Okimoto, RA ;

Brannigan, BW ;

Harris, PL ;

Haserlat, SM ;

Supko, JG ;

Haluska, FG ;

Louis, DN ;

Christiani, DC ;

Settleman, J ;

Haber, DA .

NEW ENGLAND JOURNAL OF MEDICINE, 2004, 350 (21) :2129-2139

[10]

Gefitinib or Carboplatin-Paclitaxel in Pulmonary Adenocarcinoma. [J].

Mok, Tony S. ;

Wu, Yi-Long ;

Thongprasert, Sumitra ;

Yang, Chih-Hsin ;

Chu, Da-Tong ;

Saijo, Nagahiro ;

Sunpaweravong, Patrapim ;

Han, Baohui ;

Margono, Benjamin ;

Ichinose, Yukito ;

Nishiwaki, Yutaka ;

Ohe, Yuichiro ;

Yang, Jin-Ji ;

Chewaskulyong, Busyamas ;

Jiang, Haiyi ;

Duffield, Emma L. ;

Watkins, Claire L. ;

Armour, Alison A. ;

Fukuoka, Masahiro .

NEW ENGLAND JOURNAL OF MEDICINE, 2009, 361 (10) :947-957

← 1 2 →