Stereoselective chemoenzymatic synthesis of both enantiomers of protected 4-amino-2-pentanone

被引:20
作者
Besse, P [1 ]
Ciblat, S
Canet, JL
Troin, Y
Veschambre, H
机构
[1] Univ Blaise Pascal, Lab Synth Electrosynth & Etud Syst Interet Biol, CNRS, UMR 6504, F-63177 Aubiere, France
[2] Ecole Natl Super Chim Clermont Ferrand, Lab Chim Heterocycles & Glucides, EA 987, F-63174 Aubiere, France
关键词
D O I
10.1016/S0957-4166(99)00234-7
中图分类号
O61 [无机化学];
学科分类号
070301 ; 081704 ;
摘要
An acetal protected 4-amino-2-pentanone was synthesised by two different routes in 10 and seven steps, respectively, the key step being a microbiological reduction. Both enantiomers of the amine were obtained enantiomerically pure. (C) 1999 Elsevier Science Ltd. All rights reserved.
引用
收藏
页码:2213 / 2224
页数:12
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