Phosphatidylinositol 3,5-bisphosphate defines a novel PI 3-kinase pathway in resting mouse fibroblasts

被引：130

作者：

Whiteford, CC

Brearley, CA

Ulug, ET

机构：

[1] KANSAS STATE UNIV,DIV BIOL,SECT VIROL & ONCOL,MANHATTAN,KS 66506

[2] UNIV CAMBRIDGE,DEPT PLANT SCI,CAMBRIDGE CB2 3EA,ENGLAND

来源：

BIOCHEMICAL JOURNAL | 1997年 / 323卷

关键词：

D O I：

10.1042/bj3230597

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

PtdIns(3,5)P-2 is identified as the product of an agonist-independent, wortmannin-sensitive pathway in resting mouse cells. Results are presented here to indicate that PtdIns(3,5)P-2 is formed by phosphorylation of PtdIns3P at the D-5 position, and they suggest that relatively constant cellular levels of PtdIns3P and PtdIns(3,5)P-2 are maintained by the concerted action of PtdIns3P 5-kinase and PtdIns(3,5)P-2 5-phosphatase. These studies imply a novel mechanism for the action of PtdIns-specific phosphoinositide 3-hydroxykinases in mammalian cells.

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页码：597 / 601

页数：5

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