Signal transduction cascades regulating mating, filamentation, and virulence in Cryptococcus neoformans

被引：63

作者：

Wang, P ^{[1
]}

Heitman, J ^{[1
]}

机构：

[1] Duke Univ, Med Ctr, Howard Hughes Med Inst, Dept Genet Pharmacol & Canc Biol, Durham, NC 27710 USA

来源：

CURRENT OPINION IN MICROBIOLOGY | 1999年 / 2卷 / 04期

关键词：

D O I：

10.1016/S1369-5274(99)80063-0

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Cryptococcus neoformans is a basidiomycetous fungal pathogen that infects the central nervous system. The organism has a defined sexual cycle involving mating between haploid MAT alpha and MATa cells. Recent studies have revealed signaling cascades that coordinately regulate differentation and virulence of C. neoformans. One signaling cascade involves a conserved G-protein alpha subunit and cAMP, and senses nutrients during mating and virulence. The second is a conserved mitogen activated protein (MAP) kinase cascade that senses pheromone during mating, and also regulates haploid fruiting and virulence. Interestingly, some of the MAP kinase components are encoded by the MAT locus itself, which may explain the unique association of the MAT alpha locus with physiology and virulence.

引用

页码：358 / 362

页数：5

共 33 条

[1] Signal transduction pathways regulating differentiation and pathogenicity of Cryptococcus neoformans [J].