Harnessing the Platelet Signaling Network to Produce an Optimal Hemostatic Response

被引：22

作者：

Brass, Lawrence F. ^{[1
]}

Tomaiuolo, Maurizio ^{[1
]}

Stalker, Timothy J. ^{[1
]}

机构：

[1] Univ Penn, Perelman Sch Med, Dept Med, Philadelphia, PA 19104 USA

来源：

HEMATOLOGY-ONCOLOGY CLINICS OF NORTH AMERICA | 2013年 / 27卷 / 03期

关键词：

Platelets; Hemostasis; Vascular injury; Signal transduction; Networks; G protein-coupled receptors; G proteins; Integrins; GLYCOPROTEIN IB-ALPHA; PROTEIN-TYROSINE-PHOSPHATASE; CYTOSOLIC PHOSPHOLIPASE A(2); STIMULATED HUMAN PLATELETS; ACTIVATED RECEPTORS 1; G(I) FAMILY MEMBERS; THROMBIN-RECEPTOR; ADP RECEPTORS; SHAPE CHANGE; P2X(1) RECEPTORS;

D O I：

10.1016/j.hoc.2013.02.002

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Once released into the circulation by megakaryocytes, circulating platelets can undergo rapid activation at sites of vascular injury and resist unwarranted activation, which can lead to heart attacks and strokes. Historically, the signaling mechanisms underlying the regulation of platelet activation have been approached as a collection of individual pathways unique to agonist. This review takes a different approach, casting platelet activation as the product of a signaling network, in which activating and restraining mechanisms interact in a flexible network that regulates platelet adhesiveness, cohesion between platelets, granule secretion, and the formation of a stable hemostatic thrombus.

引用

页码：381 / +

页数：30

共 184 条

[1] RGS proteins have a signalling complex: Interactions between RGS proteins and GPCRs, effectors, and auxiliary proteins [J].

Abramow-Newerly, M ;

Roy, AA ;

Nunn, C ;

Chidiac, P .

CELLULAR SIGNALLING, 2006, 18 (05) :579-591

[2]

Barr AJ, 1997, J BIOL CHEM, V272, P2223

[3] Release of angiogenesis regulatory proteins from platelet alpha granules: modulation of physiologic and pathologic angiogenesis [J].

Battinelli, Elisabeth M. ;

Markens, Beth A. ;

Italiano, Joseph E., Jr. .

BLOOD, 2011, 118 (05) :1359-1369

[4] Association of biliary glycoprotein with protein tyrosine phosphatase SHP-1 in malignant colon epithelial cells [J].

Beauchemin, N ;

Kunath, T ;

Robitaille, J ;

Chow, B ;

Turbide, C ;

Daniels, E ;

Veillette, A .

ONCOGENE, 1997, 14 (07) :783-790

[5] Imaging fibrin formation and platelet and endothelial cell activation in vivo [J].

Bellido-Martin, Lola ;

Chen, Vivien ;

Jasuja, Reema ;

Furie, Bruce ;

Furie, Barbara C. .

THROMBOSIS AND HAEMOSTASIS, 2011, 105 (05) :776-782

[6] RGS 16 is a negative regulator of SDF-1-CXCR4 signaling in megakaryocytes [J].

Berthebaud, M ;

Rivière, C ;

Jarrier, P ;

Foudi, A ;

Zhang, YY ;

Compagno, D ;

Galy, A ;

Vainchenker, W ;

Louache, F .

BLOOD, 2005, 106 (09) :2962-2968

[7] Phosphorylation of cytosolic phospholipase A2 in platelets is mediated by multiple stress-activated protein kinase pathways [J].

Börsch-Haubold, AG ;

Ghomashchi, F ;

Pasquet, S ;

Goedert, M ;

Cohen, P ;

Gelb, MH ;

Watson, SP .

EUROPEAN JOURNAL OF BIOCHEMISTRY, 1999, 265 (01) :195-203

[8] CYTOSOLIC PHOSPHOLIPASE A(2) IS PHOSPHORYLATED IN COLLAGEN-STIMULATED AND THROMBIN-STIMULATED HUMAN PLATELETS INDEPENDENT OF PROTEIN-KINASE-C AND MITOGEN-ACTIVATED PROTEIN-KINASE [J].

BORSCHHAUBOLD, AG ;

KRAMER, RM ;

WATSON, SP .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1995, 270 (43) :25885-25892

[9] Identification of FcγRIIa as the ITAM-bearing receptor mediating αIIbβ3 outside-in integrin signaling in human platelets [J].

Boylan, Brian ;

Gao, Cunji ;

Rathore, Vipul ;

Gill, Joan C. ;

Newman, Debra K. ;

Newman, Peter J. .

BLOOD, 2008, 112 (07) :2780-2786

[10] Regulating thrombus growth and stability to achieve an optimal response to injury [J].

Brass, L. F. ;

Wannemacher, K. M. ;

Ma, P. ;

Stalker, T. J. .

JOURNAL OF THROMBOSIS AND HAEMOSTASIS, 2011, 9 :66-75

← 1 2 3 4 5 6 7 8 9 10 →