Pathophysiology of multiple sclerosis

被引：88

作者：

Korn, Thomas ^{[1
]}

机构：

[1] Tech Univ Munich, Klinikum Rechts Isar, Dept Neurol, D-81675 Munich, Germany

来源：

JOURNAL OF NEUROLOGY | 2008年 / 255卷 / Suppl 6期

关键词：

multiple sclerosis; autoimmune inflammation; risk alleles; T helper cell subsets;

D O I：

10.1007/s00415-008-6001-2

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Multiple sclerosis (MS) is a chronic inflammatory demyelinating disease of the central nervous system (CNS). Both genetic and environmental causes for MS have been suggested. Recent genome-wide association studies revealed new susceptibility alleles for MS besides the HLA complex that are all related with immune functions. Whereas there is little evidence to support a purely environmental trigger for the disease in the sense of an infectious agent, the autoimmune hypothesis of MS is well established. Myelin antigen-specific CD4+ T cells become activated in the peripheral immune compartment, cross the blood-brain barrier and trigger the disease. Here, current concepts of the commitment of T cells to pro-inflammatory effector T helper cell lineages including Th 17 cells that appear to be important inducers of organ-specific autoimmunity will be discussed.

引用

页码：2 / 6

页数：5

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