A second catalytic domain in the Elp3 histone acetyltransferases: a candidate for histone demethylase activity?

被引：65

作者：

Chinenov, Y ^{[1
]}

机构：

[1] Univ Michigan, Med Ctr, Howard Hughes Med Inst, Ann Arbor, MI 48109 USA

来源：

TRENDS IN BIOCHEMICAL SCIENCES | 2002年 / 27卷 / 03期

关键词：

D O I：

10.1016/S0968-0004(02)02058-3

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A new subfamily of two-domain histone acetyltransferases (HATS) related to Elp3 has been identified. In addition to a HAT domain in the C terminus, these proteins have an N-terminal domain similar to the catalytic domain of S-adenosylmethionine radical enzymes. Two-domain organization is preserved in evolution, suggesting that both enzymatic activities are functionally or mechanistically coupled and directed towards highly conserved substrates. The functional implications of this similarity and a possible role for Elp3-related proteins as histone demethylases are discussed.

引用

页码：115 / 117

页数：3

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