A genetic dissection of the retinoid signalling pathway in the mouse

被引：89

作者：

Mark, M ^{[1
]}

Ghyselinck, NB ^{[1
]}

Wendling, O ^{[1
]}

Dupé, V ^{[1
]}

Mascrez, B ^{[1
]}

Kastner, P ^{[1
]}

Chambon, P ^{[1
]}

机构：

[1] Inst Genet & Biol Mol & Cellulaire, F-67404 Illkirch, France

来源：

PROCEEDINGS OF THE NUTRITION SOCIETY | 1999年 / 58卷 / 03期

关键词：

retinoic acid receptors; retinoic acid-binding protein; retinoic acid signalling pathway;

D O I：

10.1017/S0029665199000798

中图分类号：

R15 [营养卫生、食品卫生]; TS201 [基础科学];

学科分类号：

100403 ;

摘要：

To determine the functions of retinoic acid receptors RAR and RXR, we have systematically knocked-out their genes by homologous recombination in the embryonic stem cells and generated null-mutant mice. This approach has allowed us to perform a genetic dissection of the retinoic acid signalling pathway.

引用

页码：609 / 613

页数：5

共 33 条

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