Balancing the fat: lipid droplets and human disease

被引：488

作者：

Krahmer, Natalie ^{[1
]}

Farese, Robert V., Jr. ^{[2
,3
]}

Walther, Tobias C. ^{[1
]}

机构：

[1] Yale Univ, Sch Med, Dept Cell Biol, New Haven, CT 06510 USA

[2] Univ Calif San Francisco, Dept Med, Gladstone Inst, San Francisco, CA 94143 USA

[3] Univ Calif San Francisco, Dept Biochem & Biophys, Gladstone Inst, San Francisco, CA 94143 USA

来源：

EMBO MOLECULAR MEDICINE | 2013年 / 5卷 / 07期

关键词：

atherosclerosis; lipid droplet; lipodystrophy; metabolic syndrome; triglyceride storage; CONGENITAL GENERALIZED LIPODYSTROPHY; NECROSIS-FACTOR-ALPHA; PHOSPHOCHOLINE CYTIDYLYLTRANSFERASE-ALPHA; DIFFERENTIATION-RELATED PROTEIN; CHOLESTERYL ESTER HYDROLASE; MACROPHAGE FOAM CELLS; DIET-INDUCED OBESITY; CIDEA GENE V115F; INSULIN-RESISTANCE; HEPATIC STEATOSIS;

D O I：

10.1002/emmm.201100671

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

100103 [病原生物学]; 100218 [急诊医学];

摘要：

Lipid droplets (LDs) are dynamic, cytosolic lipid-storage organelles found in nearly all cell types. Too many or too few LDs during excess or deficient fat storage lead to many different human diseases. Recent insights into LD biology and LD protein functions shed new light on mechanisms underlying those metabolic pathologies. These findings will likely provide opportunities for treatment of diseases associated with too much or too little fat.

引用

页码：973 / 983

页数：11

共 135 条

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Massive xanthomatosis and altered composition of atherosclerotic lesions in hyperlipidemic mice lacking acyl CoA:cholesterol acyltransferase 1 [J].