Common variants of LRRK2 are not associated with sporadic Parkinson's disease

被引：40

作者：

Biskup, S

Mueller, JC

Sharma, M

Lichtner, P

Zimprich, A

Berg, D

Wüllner, U

Illig, T

Meitinger, T

Gasser, T

机构：

[1] Hertie Inst Clin Brain Res, Dept Neurodegenerat Dis, Tubingen, Germany

[2] GSF Natl Res Ctr Environm & Hlth, Inst Human Genet, Neuherberg, Germany

[3] Tech Univ Munich, Inst Med Stat & Epidemiol, D-8000 Munich, Germany

[4] Tech Univ Munich, Inst Psychiat & Psychotherapy, D-8000 Munich, Germany

[5] Med Univ Vienna, Dept Neurol, Vienna, Austria

[6] Hertie Inst Clin Brain Res, Dept Med Genet, Tubingen, Germany

[7] Univ Bonn, Dept Neurol, D-5300 Bonn, Germany

[8] GSF Natl Res Inst, Inst Epidemiol, Neuherberg, Germany

[9] Tech Univ Munich, Inst Human Genet, D-8000 Munich, Germany

来源：

ANNALS OF NEUROLOGY | 2005年 / 58卷 / 06期

关键词：

D O I：

10.1002/ana.20664

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Multiple mutations in the gene for the leucine-rich repeat kinase (LRRK2) cause autosomal dominant late-onset parkinsonism (PARK8). The Gly2019Ser mutation appears to be common in different populations. To investigate whether this novel gene influences the non-Mendelian sporadic form of Parkinson's disease, we genotyped 121 single nucleotide polymorphisms comprehensively covering the entire LRRK2 gene region in a set of 340 Parkinson's disease patients and 680 matched control subjects from Germany. No association could be demonstrated. We have therefore no evidence for the existence of a common variant in LRRK2 that has a strong influence on Parkinson's disease risk.

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页码：905 / 908

页数：4

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