Type I IFN-mediated regulation of IL-1 production in inflammatory disorders

被引：36

作者：

Ludigs, Kristina ^{[1
]}

Parfenov, Valeriy ^{[2
,3
]}

Du Pasquier, Renaud A. ^{[2
,3
]}

Guarda, Greta ^{[1
]}

机构：

[1] Univ Lausanne, Dept Biochem, CH-1066 Epalinges, Switzerland

[2] Univ Lausanne Hosp, Serv Neurol, Dept Clin Neurosci, CH-1011 Lausanne, Switzerland

[3] Univ Lausanne Hosp, Serv Immunol, CH-1011 Lausanne, Switzerland

来源：

CELLULAR AND MOLECULAR LIFE SCIENCES | 2012年 / 69卷 / 20期

基金：

瑞士国家科学基金会;

关键词：

Type I IFN; IL-1; Inflammasome; Inflammatory disorders; Autoimmunity; Multiple sclerosis; Anti-IL-1; therapy; INTERLEUKIN-1 RECEPTOR ANTAGONIST; TOLL-LIKE RECEPTORS; NF-KAPPA-B; DOUBLE-STRANDED-RNA; PLASMACYTOID DENDRITIC CELLS; FAMILIAL MEDITERRANEAN FEVER; GENOME-WIDE ASSOCIATION; TUMOR-NECROSIS-FACTOR; PROTEIN-KINASE PKR; INTERFERON-STIMULATED GENES;

D O I：

10.1007/s00018-012-0989-2

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

Although contributing to inflammatory responses and to the development of certain autoimmune pathologies, type I interferons (IFNs) are used for the treatment of viral, malignant, and even inflammatory diseases. Interleukin-1 (IL-1) is a strongly pyrogenic cytokine and its importance in the development of several inflammatory diseases is clearly established. While the therapeutic use of IL-1 blocking agents is particularly successful in the treatment of innate-driven inflammatory disorders, IFN treatment has mostly been appreciated in the management of multiple sclerosis. Interestingly, type I IFNs exert multifaceted immunomodulatory effects, including the reduction of IL-1 production, an outcome that could contribute to its efficacy in the treatment of inflammatory diseases. In this review, we summarize the current knowledge on IL-1 and IFN effects in different inflammatory disorders, the influence of IFNs on IL-1 production, and discuss possible therapeutic avenues based on these observations.

引用

页码：3395 / 3418

页数：24

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