CD14 and LBP in endotoxemia and infections caused by Gram-negative bacteria

被引：18

作者：

Heumann, D ^{[1
]}

机构：

[1] CHU Vaudois, Div Infect Dis, CH-1011 Lausanne, Switzerland

来源：

JOURNAL OF ENDOTOXIN RESEARCH | 2001年 / 7卷 / 06期

关键词：

D O I：

10.1177/09680519010070060701

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

It is now well recognized that plasma LPS-binding protein (LBP) and membrane CD14 present at the surface of cells of the myelo/monocytic lineage are central molecules of the innate immune system, in response to LPS or to bacterial products. This paper reviews the role of LBP and CD14 in models of endotoxemia and infection.

引用

页码：439 / 441

页数：3

共 12 条

[1] Inhibition by a CD14 monoclonal antibody of lipopolysaccharide binding to murine macrophages [J].

Adachi, Y ;

Satokawa, C ;

Saeki, M ;

Ohno, N ;

Tamura, H ;

Tanaka, S ;

Yadomae, T .

JOURNAL OF ENDOTOXIN RESEARCH, 1999, 5 (03) :139-146

[2] LIPOPOLYSACCHARIDE-BINDING PROTEIN AS A MAJOR PLASMA-PROTEIN RESPONSIBLE FOR ENDOTOXEMIC SHOCK [J].

GALLAY, P ;

HEUMANN, D ;

LEROY, D ;

BARRAS, C ;

GLAUSER, MP .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1993, 90 (21) :9935-9938

[3] Resistance to endotoxin shock and reduced dissemination of gram-negative bacteria in CD14-deficient mice [J].

Haziot, A ;

Ferrero, E ;

Kontgen, F ;

Hijiya, N ;

Yamamoto, S ;

Silver, J ;

Stewart, CL ;

Goyert, SM .

IMMUNITY, 1996, 4 (04) :407-414

[4] Lipopolysaccharide-binding protein is required to combat a murine Gram-negative bacterial infection [J].

Jack, RS ;

Fan, XL ;

Bernheiden, M ;

Rune, G ;

Ehlers, M ;

Weber, A ;

Kirsch, G ;

Mentel, R ;

Furll, B ;

Freudenberg, M ;

Schmitz, G ;

Stelter, F ;

Schutt, C .

NATURE, 1997, 389 (6652) :742-745

[5]

Le Roy D, 1999, J IMMUNOL, V162, P7454

[6] Critical role of lipopolysaccharide-binding protein and CD14 in immune responses against gram-negative bacteria [J].

Le Roy, D ;

Di Padova, F ;

Adachi, Y ;

Glauser, MP ;

Calandra, T ;

Heumann, D .

JOURNAL OF IMMUNOLOGY, 2001, 167 (05) :2759-2765

[7] Antibodies against CD14 protect primates from endotoxin-induced shock [J].

Leturcq, DJ ;

Moriarty, AM ;

Talbott, G ;

Winn, RK ;

Martin, TR ;

Ulevitch, RJ .

JOURNAL OF CLINICAL INVESTIGATION, 1996, 98 (07) :1533-1538

[8] Anti-CD14 mAb treatment provides therapeutic benefit after in vivo exposure to endotoxin [J].

Schimke, J ;

Mathison, J ;

Morgiewicz, J ;

Ulevitch, RJ .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1998, 95 (23) :13875-13880

[9] STRUCTURE AND FUNCTION OF LIPOPOLYSACCHARIDE BINDING-PROTEIN [J].

SCHUMANN, RR ;

LEONG, SR ;

FLAGGS, GW ;

GRAY, PW ;

WRIGHT, SD ;

MATHISON, JC ;

TOBIAS, PS ;

ULEVITCH, RJ .

SCIENCE, 1990, 249 (4975) :1429-1431

[10] Blockade of CD14 increases Shigella-mediated invasion and tissue destruction [J].

Wennerås, C ;

Ave, P ;

Huerre, M ;

Arondel, J ;

Ulevitch, RJ ;

Mathison, JC ;

Sansonetti, P .

JOURNAL OF IMMUNOLOGY, 2000, 164 (06) :3214-3221

← 1 2 →