The role of osteopontin in inflammatory processes

被引：463

作者：

Lund, Susan Amanda ^{[1
]}

Giachelli, Cecilia M. ^{[1
]}

Scatena, Marta ^{[1
]}

机构：

[1] Univ Washington, Dept Bioengn, Seattle, WA 98195 USA

来源：

JOURNAL OF CELL COMMUNICATION AND SIGNALING | 2009年 / 3卷 / 3-4期

关键词：

Inflammation; Matricellular protein; Osteopontin;

D O I：

10.1007/s12079-009-0068-0

中图分类号：

Q2 [细胞生物学];

学科分类号：

071013 [干细胞生物学];

摘要：

Osteopontin (OPN) is a matricellular protein that mediates diverse biological functions. OPN is involved in normal physiological processes and is implicated in the pathogenesis of a variety of disease states, including atherosclerosis, glomerulonephritis, cancer, and several chronic inflammatory diseases. Through interactions with several integrins, OPN mediates cell migration, adhesion, and survival in many cell types. OPN also functions as a Th1 cytokine, promotes cell-mediated immune responses, and plays a role in chronic inflammatory and autoimmune diseases. Besides its function in inflammation, OPN is also a regulator of biomineralization and a potent inhibitor of vascular calcification.

引用

收藏

页码：311 / 322

页数：12

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