PEG-coated nanospheres from amphiphilic diblock and multiblock copolymers: Investigation of their drug encapsulation and release characteristics

被引:239
作者
Peracchia, MT
Gref, R
Minamitake, Y
Domb, A
Lotan, N
Langer, R
机构
[1] MIT,DEPT CHEM ENGN,CAMBRIDGE,MA 02139
[2] UNIV PARMA,DIPARTIMENTO FARMACEUT,I-43100 PARMA,ITALY
[3] ECOLE NATL SUPER IND CHIM,LCPM,F-54001 NANCY,FRANCE
[4] SUNTORY LTD,GUNMA,JAPAN
[5] HEBREW UNIV JERUSALEM,DEPT PHARMACEUT CHEM,IL-91120 JERUSALEM,ISRAEL
[6] TECHNION ISRAEL INST TECHNOL,DEPT BIOMED ENGN,IL-32000 HAIFA,ISRAEL
基金
美国国家卫生研究院;
关键词
D O I
10.1016/S0168-3659(96)01597-0
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
The development of long-circulating carriers capable of continuously delivering drugs intravenously provides a potential approach to achieve targeting of drugs to specific sites of action. In this research, polyethylene glycol (PEG)-coated nanospheres were prepared in a single step process using amphiphilic diblock and multiblock copolymers, and their drug encapsulation properties and release characteristics were investigated in vitro, The results obtained indicate that the parameters controlling drug release characteristics of these nanospheres are the chemical composition of their hydrophobic core (i.e. polyester or polyanhydride), as well as the molecular weight and surface density of their hydrophilic (i.e. PEG) chains.
引用
收藏
页码:223 / 231
页数:9
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