Osteoarthritis as a disease of mechanics

被引：553

作者：

Felson, D. T. ^{[1
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机构：

[1] Boston Univ, Sch Med, Clin Epidemiol Res & Training Unit, Boston, MA 02118 USA

[2] Univ Manchester, Arthritis Res UK Epidemiol Unit, Manchester, Lancs, England

来源：

OSTEOARTHRITIS AND CARTILAGE | 2013年 / 21卷 / 01期

关键词：

Osteoarthritis; Biomechanics; Inflammation; ANTERIOR CRUCIATE LIGAMENT; BONE-MARROW EDEMA; RADIOGRAPHIC OSTEOARTHRITIS; HIP OSTEOARTHRITIS; KNEE OSTEOARTHRITIS; ASSOCIATION; PROGRESSION; RISK; PREVALENCE; ALIGNMENT;

D O I：

10.1016/j.joca.2012.09.012

中图分类号：

R826.8 [整形外科学]; R782.2 [口腔颌面部整形外科学]; R726.2 [小儿整形外科学]; R62 [整形外科学（修复外科学）];

学科分类号：

100224 [整形外科学];

摘要：

Mechanics means relating to or caused by movement or physical forces. In this paper, I shall contend that osteoarthritis (OA) is almost always caused by increased physical forces causing damage to a joint. While examples of joint injury causing OA are numerous, I shall contend that most or almost all OA is caused in part by mechanically induced injury to joint tissues. Further, once joint pathology has developed, as is the case for almost all clinical OA, pathomechanics overwhelms all other factors in causing disease progression. Treatments which correct the pathomechanics have long lasting favorable effects on pain and joint function compared with treatments that suppress inflammation which have only temporary effects. I shall lastly contend that the mechanically induced joint injury leads to variable inflammatory responses but that the role of this inflammation in worsening structural damage in an already osteoarthritic joint has not yet been proven. (C) 2012 Osteoarthritis Research Society International. Published by Elsevier Ltd. All rights reserved.

引用

页码：10 / 15

页数：6

共 43 条

[1]

CAM-TYPE DEFORMITIES STRONGLY PREDICT TOTAL HIP REPLACEMENT WITHIN 5 YEARS IN THOSE WITH EARLY SYMPTOMATIC OA: A PROSPECTIVE COHORT STUDY (CHECK) [J].