Serum levels of receptor activator of nuclear factor κB ligand (RANKL) in healthy women and men

被引：29

作者：

Kerschan-Schindl, K. ^{[1
]}

Wendlova, J. ^{[2
,3
]}

Kudlacek, S. ^{[4
]}

Gleiss, A. ^{[5
]}

Woloszczuk, W. ^{[6
]}

Pietschmann, P. ^{[7
,8
]}

机构：

[1] Med Univ Vienna, Dept Phys Med & Rehabil, A-1090 Vienna, Austria

[2] Univ Hosp, Osteol Unit, Bratislava, Slovakia

[3] Polyclin Kramare, Bratislava, Slovakia

[4] Krankenhaus Barmherzigen Brueder, Dept Internal Med, Vienna, Austria

[5] Core Unit Med Stat & Informat, Sect Clin Biometr, Vienna, Austria

[6] Ludwig Boltzmann Inst Rheumatol, Vienna, Austria

[7] Med Univ Vienna, Dept Pathophysiol, A-1090 Vienna, Austria

[8] Ludwig Boltzmann Inst Aging Res, Vienna, Austria

来源：

EXPERIMENTAL AND CLINICAL ENDOCRINOLOGY & DIABETES | 2008年 / 116卷 / 08期

关键词：

bone metabolism; free RANKL (receptor activator of nuclear factor kappa B ligand); total RANKL; age; gender;

D O I：

10.1055/s-2007-993142

中图分类号：

R5 [内科学];

学科分类号：

1002 [临床医学]; 100201 [内科学];

摘要：

Background: Osteoporosis is one of the most common conditions associated with aging. It is based on an excess of bone resorption over bone formation, leading to an imbalance of bone turnover. The receptor activator of nuclear factor kappa B ligand (RANKL) is ail important regulator of bone metabolism. Objective: The aim of this investigation was to evaluate potential age- and gender-related changes in free RANKL and total RANKL (free RANKL+ RANKL/osteoprotegerin complexes). Methods: Two hundred and forty Volunteers with a median age of 48 years were included in the study. Serum levels of free RANKL and total RANKL were evaluated. Results: On average, men have a 1.77-fold higher free RANKL level and a 2.12-fold higher free/total RANKL ratio than women of the same age. On average, the RANKL levels decrease by approximately 13 % every five years. Conclusion: This study showed that serum levels of free RANKL and total RANKL decrease with age, and also revealed some gender-related differences.

引用

页码：491 / 495

页数：5

共 30 条

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Increased RANKL/OPG mRNA ratio in iliac bone biopsies from women with hip fractures [J].