Diminished serum levels of free IGF-I in patients with diabetic retinopathy

被引：10

作者：

Feldmann, B

Lang, GE

Arnavaz, A

Jehle, P

Böhm, BO

Lang, GK

机构：

[1] Univ Ulm, Med Klin, Sekt Endokrinol, Innere Med Abt 1, D-89081 Ulm, Germany

[2] Univ Ulm, Augenklin, D-89081 Ulm, Germany

来源：

OPHTHALMOLOGE | 1999年 / 96卷 / 05期

关键词：

diabetic retinopathy; insulin-like growth factor-I (IGF-I); insulin-like growth factor binding protein-1; -3; metabolic control; glycosylated hemoglobin (HbA1c);

D O I：

10.1007/s003470050409

中图分类号：

R77 [眼科学];

学科分类号：

100212 ;

摘要：

Background: Growth factors like IGF-I have been implicated in the pathogenesis of diabetic retinopathy. To investigate the role and bioavailability of IGF-I we measured not only total but also free serum levels of IGF-I in diabetic patients. Methods: A total of 159 patients with and without diabetic retinopathy were investigated (60 diabetic patients without and 99 with clinically and angiographically diagnosed diabetic retinopathy). One hundred ten healthy volunteers served as controls. The data were analyzed by Student's t-test, analysis of variance and correlation; P < 0.05 was considered statistically significant. Results: Diabetic patients with retinopathy showed significantly lower serum levels-of free IGF-I than diabetics without retinopathy. Free IGF-I was negatively correlated with glycosylated hemoglobin Ic. IGFBP-3 levels were diminished in type 2 patients with diabetic retinopathy, while type 1 patients with diabetic retinopathy showed higher IGFBP-1 levers. Conclusion: Diabetic patients with retinopathy showed significantly reduced serum levels of free IGF-I. Low IGF-I was associated with poor metabolic control.

引用

页码：300 / 305

页数：6

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