L-BLP25 vaccine plus letrozole for breast cancer Is translation possible?

被引：11

作者：

DeGregorio, Michael ^{[1
]}

Wurz, Gregory T. ^{[1
]}

Gutierrez, Audrey ^{[1
]}

Wolf, Michael ^{[2
]}

机构：

[1] Univ Calif Davis, Dept Internal Med, Div Hematol & Oncol, Sacramento, CA 95817 USA

[2] Merck Serono, Dept ImmunoOncol, Darmstadt, Germany

来源：

ONCOIMMUNOLOGY | 2012年 / 1卷 / 08期

关键词：

L-BLP25; Letrozole; breast cancer; MMT model; Tamoxifen; IMMUNE-RESPONSE; INHIBITION;

D O I：

10.4161/onci.21129

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

We have recently reported immunomodulatory effects for tamoxifen and letrozole on the L-BLP25 (Stimuvax (R))-induced immune response in a MUC1-expressing breast cancer mouse model. While neither tamoxifen nor letrozole appeared to interfere with the Th1-polarized cytokine response induced by L-BLP25, only letrozole increased the survival advantage of L-BLP25.

引用

页码：1422 / 1424

页数：3

共 10 条

[1] The Effects of Tamoxifen on Immunity [J].

Behjati, S. ;

Frank, M. H. .

CURRENT MEDICINAL CHEMISTRY, 2009, 16 (24) :3076-3080

[2] The Cytoplasmic Tail of MUC1: A Very Busy Place [J].

Carson, Daniel D. .

SCIENCE SIGNALING, 2008, 1 (27) :pe35

[3]

COLLINS JL, 1989, CANCER IMMUNOL IMMUN, V29, P17

[4] Progression to malignancy in the polyoma middle T oncoprotein mouse breast cancer model provides a reliable model for human diseases [J].

Lin, EY ;

Jones, JG ;

Li, P ;

Zhu, UY ;

Whitney, KD ;

Muller, WJ ;

Pollard, JW .

AMERICAN JOURNAL OF PATHOLOGY, 2003, 163 (05) :2113-2126

[5] Inhibition of CD4+25+ T regulatory cell function implicated in enhanced immune response by low-dose cyclophosphamide [J].

Lutsiak, MEC ;

Semnani, RT ;

De Pascalis, R ;

Kashmiri, SVS ;

Schlom, J ;

Sabzevari, H .

BLOOD, 2005, 105 (07) :2862-2868

[6] L-BLP25 Vaccine plus Letrozole Induces a TH1 Immune Response and Has Additive Antitumor Activity in MUC1-Expressing Mammary Tumors in Mice [J].

Mehta, Neelima R. ;

Wurz, Gregory T. ;

Burich, Rebekah A. ;

Greenberg, Brittany E. ;

Griffey, Stephen ;

Gutierrez, Audrey ;

Bell, Katie E. ;

McCall, Jamie L. ;

Wolf, Michael ;

DeGregorio, Michael .

CLINICAL CANCER RESEARCH, 2012, 18 (10) :2861-2871

[7] CD25 Blockade Depletes and Selectively Reprograms Regulatory T Cells in Concert with Immunotherapy in Cancer Patients [J].

Rech, Andrew J. ;

Mick, Rosemarie ;

Martin, Sunil ;

Recio, Adri ;

Aqui, Nicole A. ;

Powell, Daniel J., Jr. ;

Colligon, Theresa A. ;

Trosko, Jennifer A. ;

Leinbach, Leah I. ;

Pletcher, Charles H. ;

Tweed, Carol K. ;

DeMichele, Angela ;

Fox, Kevin R. ;

Domchek, Susan M. ;

Riley, James L. ;

Vonderheide, Robert H. .

SCIENCE TRANSLATIONAL MEDICINE, 2012, 4 (134)

[8] Therapeutic Cancer Vaccines: Current Status and Moving Forward [J].

Schlom, Jeffrey .

JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE, 2012, 104 (08) :599-613

[9] Immoderate inhibition of estrogen by anastrozole enhances the severity of experimental polyarthritis [J].

Wang Jingxuan ;

Zhang Qingyuan ;

Jin Shi ;

Feng Meiyan ;

Kang Xinmei ;

Zhao Shu ;

Liu Shuling ;

Zhao Wenhui .

EXPERIMENTAL GERONTOLOGY, 2009, 44 (6-7) :398-405

[10]

Yamaue H, 1991, J Clin Lab Immunol, V35, P165

← 1 →