Lobophorins A and B, new antiinflammatory macrolides produced by a tropical marine bacterium

被引：97

作者：

Jiang, ZD ^{[1
]}

Jensen, PR ^{[1
]}

Fenical, W ^{[1
]}

机构：

[1] Univ Calif San Diego, Scripps Inst Oceanog, Ctr Marine Biotechnol & Biomed, La Jolla, CA 92093 USA

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1999年 / 9卷 / 14期

关键词：

D O I：

10.1016/S0960-894X(99)00337-6

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Two new antiinflammatory macrolides, lobophorins A and B (1 and 2), have been isolated from fermentation broths of a marine bacterium isolated from the surface the Caribbean brown alga Lobophora variegata (Dictyotales). The new compounds, distantly related to antibiotics of the kijanimicin class, are potent inhibitors of topical PMA-induced edema in the mouse ear assay when administered either topically or IP. (C) 1999 Published by Elsevier Science Ltd. All rights reserved.

引用

页码：2003 / 2006

页数：4

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