Structure of phosphorus-containing peptide ligands. X-ray and NMR structural study of free ligand and rhodium complex

被引:26
作者
Gilbertson, SR [1 ]
Chen, GH [1 ]
Kao, J [1 ]
Beatty, A [1 ]
Campana, CF [1 ]
机构
[1] SIEMENS ANALYT XRAY SYST INC, MADISON, WI 53719 USA
关键词
D O I
10.1021/jo970773e
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
The structure of a series of phosphorus-containing peptides was studied, The X-ray structure of a phosphorus-containing dodecapeptide is reported. Analysis of the solution structure of similar phosphorus-containing peptides before and after coordination of rhodium is also reported. In both the solid state and in solution, the peptides were found to exist in a mixture of a-helical and 3(10) helical conformations. Coordination of rhodium to the i, i + 4 orientated phosphine groups appears to alter the conformational preference.
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页码:5557 / 5566
页数:10
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