Tight junction proteins in the skin

被引：59

作者：

Brandner, JM ^{[1
]}

Kief, S ^{[1
]}

Wladykowski, E ^{[1
]}

Houdek, P ^{[1
]}

Moll, I ^{[1
]}

机构：

[1] Univ Hamburg Hosp, Dept Dermatol & Venerol, D-20246 Hamburg, Germany

来源：

SKIN PHARMACOLOGY AND PHYSIOLOGY | 2006年 / 19卷 / 02期

关键词：

occludin; claudins; protein ZO-1; skin barrier function; transepidermal water loss;

D O I：

10.1159/000091973

中图分类号：

R75 [皮肤病学与性病学];

学科分类号：

100206 ;

摘要：

It has long been accepted that tight junctions (TJ) are crucial for the formation and maintenance of the paracellular barrier and for cell polarity in simple epithelia and endothelia. Moreover, it is long known that they play a role in barrier function of amphibian skin. However, only in recent years were TJ and TJ proteins identified in the epidermis of men and mice. Their involvement in the barrier function of mammalian skin has been shown. This review summarizes our current knowledge about TJ and TJ proteins in mammalian skin.

引用

页码：71 / 77

页数：7

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