Corticostriatal functional connectivity predicts transition to chronic back pain

被引：788

作者：

Baliki, Marwan N. ^{[1
]}

Petre, Bogdan ^{[1
]}

Torbey, Souraya ^{[1
]}

Herrmann, Kristina M. ^{[1
]}

Huang, Lejian ^{[1
]}

Schnitzer, Thomas J. ^{[2
]}

Fields, Howard L. ^{[3
,4
]}

Apkarian, A. Vania ^{[1
,5
,6
]}

机构：

[1] Northwestern Univ, Feinberg Sch Med, Dept Physiol, Chicago, IL 60611 USA

[2] Northwestern Univ, Feinberg Sch Med, Dept Rheumatol, Chicago, IL 60611 USA

[3] Univ Calif San Francisco, Dept Neurol, San Francisco, CA 94143 USA

[4] Univ Calif San Francisco, Ernest Gallo Clin & Res Ctr, San Francisco, CA 94143 USA

[5] Northwestern Univ, Feinberg Sch Med, Dept Anesthesia, Chicago, IL 60611 USA

[6] Northwestern Univ, Feinberg Sch Med, Dept Surg, Chicago, IL 60611 USA

来源：

NATURE NEUROSCIENCE | 2012年 / 15卷 / 08期

关键词：

BRAIN;

D O I：

10.1038/nn.3153

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The mechanism of brain reorganization in pain chronification is unknown. In a longitudinal brain imaging study, subacute back pain (SBP) patients were followed over the course of 1 year. When pain persisted (SBPp, in contrast to recovering SBP and healthy controls), brain gray matter density decreased. Initially greater functional connectivity of nucleus accumbens with prefrontal cortex predicted pain persistence, implying that corticostriatal circuitry is causally involved in the transition from acute to chronic pain.

引用

页码：1117 / +

页数：5

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