NTproBNP concentrations in healthy children

被引：14

作者：

Koerbin, G. ^{[1
,2
]}

Abhayaratna, W. P. ^{[3
,4
]}

Potter, J. M. ^{[1
,3
]}

Apostoloska, S. ^{[1
]}

Telford, R. D. ^{[3
,4
]}

Hickman, P. E. ^{[1
,3
]}

机构：

[1] ACT Pathol, Canberra, ACT, Australia

[2] Univ Canberra, Fac Sci Appl, Canberra, ACT 2601, Australia

[3] Australian Natl Univ, Sch Med, Canberra, ACT, Australia

[4] Canberra Hosp, Acad Unit Internal Med, Canberra, ACT, Australia

来源：

CLINICAL BIOCHEMISTRY | 2012年 / 45卷 / 15期

关键词：

NT-proBNP; Children; PEDIATRIC REFERENCE INTERVALS; BRAIN NATRIURETIC PEPTIDE;

D O I：

10.1016/j.clinbiochem.2012.05.008

中图分类号：

R446 [实验室诊断]; R-33 [实验医学、医学实验];

学科分类号：

100118 [医学信息学]; 100208 [临床检验诊断学];

摘要：

Introduction: There have been limited studies generating BNP and NT-proBNP reference intervals for paediatric populations. We prospectively assessed NT-proBNP levels in a cohort of 854 healthy school children from the Lifestyle of Our Kids (LOOK) prospective longitudinal study. Materials and methods: NT-proBNP analysis was performed on 172 girls and 212 boys with average age 8.1 years, 183 girls and 181 boys, average age 10.1 years and 183 girls and 180 boys with average age 11.9 years. Data were stratified according to age and gender with the median, range of results and 2.5th and 97.5th percentiles calculated Results: There were no significant differences between males and females at any of the 3 study ages. Significant differences were seen between the 8 and 12 year-olds, 10 and 12 year-olds and the 8 and 12 year-old boys. Discussion: Our study demonstrated that NT-proBNP concentrations in healthy children progressively decline between ages 8 and 12 years. Our selection of unambiguously healthy children produced similar median but lower 97.5th percentile NT-proBNP concentrations to previously published studies. (C) 2012 The Canadian Society of Clinical Chemists. Published by Elsevier Inc. All rights reserved.

引用

页码：1158 / 1160

页数：3

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