Conjugation between bacterial and mammalian cells

被引：125

作者：

Waters, VL ^{[1
]}

机构：

[1] Univ Calif San Diego, Sch Med, Dept Med, La Jolla, CA 92093 USA

来源：

NATURE GENETICS | 2001年 / 29卷 / 04期

关键词：

D O I：

10.1038/ng779

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Bacterial conjugation, in which DNA is transferred from one bacterium to another, was first reported in 1946 and found to be mediated by the F factor(1). Although the F and RK2/RP4 prototypic plasmids can mediate the transfer of DNA from bacteria to yeast(2), there has been no evidence of classical bacterial conjugation to higher eukaryotes. Here, I present evidence of such transfer, using Escherichia coli, the RK2 plasmid system and Chinese hamster ovary CHO K1 cells.

引用

页码：375 / 376

页数：2

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