Neutrophils cast extracellular traps in response to protozoan parasites

被引:78
作者
Abdallah, Delbert S. Abi [1 ]
Denkers, Eric Y. [1 ]
机构
[1] Cornell Univ, Coll Vet Med, Dept Microbiol & Immunol, Ithaca, NY 14853 USA
关键词
protozoan parasite; neutrophils; extracellular traps; anti-microbial defense; toxoplasma;
D O I
10.3389/fimmu.2012.00382
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
071005 [微生物学]; 100108 [医学免疫学];
摘要
Release of extracellular traps by neutrophils is a now well-established phenomenon that contributes to the innate response to extracellular bacterial and fungal pathogens. The importance of NETs during protozoan infection has been less explored, but recent findings suggest an emerging role for release of neutrophil-derived extracellular DNA in response to this class of microbial pathogens. The present review summarizes findings to date regarding elicitation of NETs by Toxoplasma gondii, Plasmodium falciparum, Eimeria bovis, and Leishmania spp.
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页数:6
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