Tanikolide, a toxic and antifungal lactone from the marine cyanobacterium Lyngbya majuscula

被引：118

作者：

Singh, IP ^{[1
]}

Milligan, KE ^{[1
]}

Gerwick, WH ^{[1
]}

机构：

[1] Oregon State Univ, Coll Pharm, Corvallis, OR 97331 USA

来源：

JOURNAL OF NATURAL PRODUCTS | 1999年 / 62卷 / 09期

关键词：

D O I：

10.1021/np990162c

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

A new brine-shrimp toxic and antifungal compound, tanikolide 1, has been isolated from the lipid extract of a Madagascan collection of the marine cyanobacterium Lyngbya majuscula. The structure of tanikolide was determined by spectroscopic methods, relying heavily on 2D NMR spectroscopy. The absolute configuration at C-5 of tanikolide was established as R by oxidizing the primary alcohol to an acid and analyzing the corresponding (R)- and (S)-PGME amide derivatives by H-1 NMR.

引用

页码：1333 / 1335

页数：3

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