In vitro efficacy of antinialarial drugs against Plasmodium vivax on the western border of Thailand

被引：43

作者：

Chotivanich, K

Udomsangpetch, R

Chierakul, W

Newton, PN

Ruangveerayuth, R

Pukrittayakamee, S

Looareesuwan, S

White, NJ

机构：

[1] Mahidol Univ, Fac Trop Med, Bangkok 10400, Thailand

[2] Mahidol Univ, Dept Pathobiol, Fac Sci, Bangkok 10400, Thailand

[3] Churchill Hosp, Ctr Clin Vaccinol & Trop Med, Oxford, England

[4] Mae Sot Hosp, Tak, Thailand

来源：

AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE | 2004年 / 70卷 / 04期

关键词：

D O I：

10.4269/ajtmh.2004.70.395

中图分类号：

R1 [预防医学、卫生学];

学科分类号：

1004 ; 120402 ;

摘要：

The susceptibility of 20 isolates of Plasmodium vivax on the Thailand-Myanmar border to seven antimalarial drugs was evaluated using the schizont maturation inhibition technique. The geometric mean 50% inhibition concentration (IC50) values were quinine 308 ng/mL, amodiaquine = 14 ng/mL, chloroquine = 50 ng/mL, mefloquine f127 ng/mL, sulfadoxine/pyrimethamine (80:1) = 800/10 ng/mL, pyrimethamine = 8 ng/mL, and artesunate = 0.5 ng/mL. Compared with P. falciparum in this area, P. vivax was more sensitive to chloroquine and artesunate, equally sensitive to quinine, and more resistant to mefloquine.

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收藏

页码：395 / 397

页数：3

相关论文

共 18 条

[1] RESISTANCE TO CHLOROQUINE BY PLASMODIUM-VIVAX IN IRIAN-JAYA, INDONESIA [J].

BAIRD, JK ;

BASRI, H ;

PURNOMO ;

BANGS, MJ ;

SUBIANTO, B ;

PATCHEN, LC ;

HOFFMAN, SL .

AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE, 1991, 44 (05) :547-552

[2]

BROCKELMAN CR, 1982, B WORLD HEALTH ORGAN, V60, P423

[3] Plasmodium falciparum antimalarial drug susceptibility on the north-western border of Thailand during five years of extensive use of artesunate-mefloquine [J].

Brockman, A ;

Price, RN ;

van Vugt, M ;

Heppner, DG ;

Walsh, D ;

Sookto, P ;

Wimonwattrawatee, T ;

Looareesuwan, S ;

White, NJ ;

Nosten, F .

TRANSACTIONS OF THE ROYAL SOCIETY OF TROPICAL MEDICINE AND HYGIENE, 2000, 94 (05) :537-544

[4]

CHILDS G E, 1987, Southeast Asian Journal of Tropical Medicine and Public Health, V18, P438

[5] SYNERGISTIC ANTIMALARIAL ACTIVITY OF PYRIMETHAMINE AND SULFADOXINE AGAINST PLASMODIUM-FALCIPARUM INVITRO [J].

CHULAY, JD ;

WATKINS, WM ;

SIXSMITH, DG .

AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE, 1984, 33 (03) :325-330

[6]

Dua VK, 1996, TROP MED INT HEALTH, V1, P816

[7] Sensitivity in vitro of Plasmodium falciparum to three currently used antimalarial drugs on the western border of Thailand [J].

Fèvre, EM ;

Barnish, G ;

Yamokgul, P ;

Rooney, W .

TRANSACTIONS OF THE ROYAL SOCIETY OF TROPICAL MEDICINE AND HYGIENE, 1999, 93 (02) :180-184

[8]

KIDSON C, 1999, SE ASIAN J TROP M S4, V30, P28

[9] MALARIA DURING PREGNANCY IN AN AREA OF UNSTABLE ENDEMICITY [J].

NOSTEN, F ;

TERKUILE, F ;

MAELANKIRRI, L ;

DECLUDT, B ;

WHITE, NJ .

TRANSACTIONS OF THE ROYAL SOCIETY OF TROPICAL MEDICINE AND HYGIENE, 1991, 85 (04) :424-429

[10] Effects of Plasmodium vivax malaria in pregnancy [J].

Nosten, F ;

McGready, R ;

Simpson, JA ;

Thwai, KL ;

Balkan, S ;

Cho, T ;

Hkirijaroen, L ;

Looareesuwan, S ;

White, NJ .

LANCET, 1999, 354 (9178) :546-549