Toward glycosylated peptidic porphyrins: a new strategy for PDT?

被引：37

作者：

Sol, V

Blais, JC

Bolbach, G

Carre, V

Granet, R

Guilloton, M

Spiro, M

Krausz, P

机构：

[1] UNIV LIMOGES,LAB CHIM SUBST NAT,F-87060 LIMOGES,FRANCE

[2] UNIV PARIS 06,LAB CHIM ORGAN STRUCT & BIOL,CNRS,F-75005 PARIS,FRANCE

[3] UNIV LIMOGES,INST BIOTECHNOL,F-87060 LIMOGES,FRANCE

来源：

TETRAHEDRON LETTERS | 1997年 / 38卷 / 36期

关键词：

D O I：

10.1016/S0040-4039(97)01489-5

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

New porphyrins bearing glycosyl groups and alanine moieties to improve targeting on malignant cells were synthesised in four steps. Fluorescence properties were extensively determined and indicated aggregate formation in water. These compounds produced O-1(2). Photocytotoxicity of these molecules against K562 Leukemia cell line was compared to the effect of hematoporphyrin. (C) 1997 Published by Elsevier Science Ltd.

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页码：6391 / 6394

页数：4

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