Activation of maternal toll-like receptor-2 causes social deficits and memory impairment in female offspring

被引：3

作者：

Lee, Younghwa ^{[1
,3
]}

Jeon, Se Jin ^{[1
,3
]}

Choi, Ji Woong ^{[4
,5
]}

Ryu, Jong Hoon ^{[1
,2
,3
]}

机构：

[1] Kyung Hee Univ, Coll Pharm, Dept Life & Nanopharmaceut Sci, Seoul 130701, South Korea

[2] Kyung Hee Univ, Coll Pharm, Dept Oriental Pharmaceut Sci, Seoul 130701, South Korea

[3] Kyung Hee Univ, Coll Pharm, Kyung Hee East West Pharmaceut Res Inst, Seoul 130701, South Korea

[4] Gachon Univ, Coll Pharm, Lab Neuropharmacol, Inchon, South Korea

[5] Gachon Univ, Gachon Inst Pharmaceut Sci, Inchon, South Korea

来源：

NEUROREPORT | 2016年 / 27卷 / 04期

基金：

新加坡国家研究基金会;

关键词：

cognitive impairment; maternal immune activation; offspring; social interaction; toll-like receptor-2; zymosan; IMMUNE ACTIVATION; MICE; BEHAVIOR; HIPPOCAMPUS; ZYMOSAN; INNATE; SCHIZOPHRENIA; NEUROGENESIS; EXPRESSION; INFECTION;

D O I：

10.1097/WNR.0000000000000517

中图分类号：

Q189 [神经科学];

学科分类号：

071006 [神经生物学];

摘要：

To study the relevance of the activation of toll-like receptor-2 and abnormal behavioral properties, we introduced prenatal zymosan, a toll-like receptor-2 ligand, to investigate the effect of maternal immunity on offspring behavior. Only female offspring showed impaired social and cognitive function, suggesting that zymosan may influence females' behavior. Copyright (C) 2016 Wolters Kluwer Health, Inc. All rights reserved.

引用

收藏

页码：224 / 229

页数：6

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