Mining the Wnt pathway for cancer therapeutics

被引：604

作者：

Barker, Nick ^{[1
]}

Clevers, Hans ^{[1
]}

机构：

[1] Netherlands Inst Dev Biol, Hubrecht Lab, NL-3584 CT Utrecht, Netherlands

来源：

NATURE REVIEWS DRUG DISCOVERY | 2006年 / 5卷 / 12期

关键词：

D O I：

10.1038/nrd2154

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Aberrant activation of the Wnt pathway is implicated in driving the formation of various human cancers, particularly those of the digestive tract. Inhibition of aberrant Wnt pathway activity in cancer cell lines efficiently blocks their growth, highlighting the great potential of therapeutics designed to achieve this in cancer patients. Here we provide an overview of the promise and pitfalls of current drug development strategies striving to inhibit the Wnt pathway and present new opportunities for therapeutic intervention.

引用

页码：997 / 1014

页数：18

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