Mammalian Toll-like receptors

被引：450

作者：

Akira, S

机构：

[1] Osaka Univ, Res Inst Micorbial dis, Dept Host Def, Suita, Osaka 5650871, Japan

[2] Japan Sci & Technol Corp, SORST, Suita, Osaka 5650871, Japan

来源：

CURRENT OPINION IN IMMUNOLOGY | 2003年 / 15卷 / 01期

关键词：

D O I：

10.1016/S0952-7915(02)00013-4

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Toll-like receptors (TLRs) are essential in the host defense against microbial pathogens. Individual TLRs recognize distinct structural components of pathogens and evoke inflammatory responses. Recent evidence indicates that TLRs recognize not only bacteria and fungi but also viruses. The molecular mechanisms by which TLRs induce differential gene expression are now beginning to be clarified.

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页码：5 / 11

页数：7

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