A novel dual-adhesive and bioactive hydrogel activated by bioglass for wound healing

被引：151

作者：

Gao, Long ^{[1
,2
]}

Zhou, Yanling ^{[1
,2
]}

Peng, Jinliang ^{[3
]}

Xu, Chen ^{[1
]}

Xu, Qing ^{[1
,2
]}

Xing, Min ^{[1
,2
]}

Chang, Jiang ^{[1
,2
]}

机构：

[1] Chinese Acad Sci, State Key Lab High Performance Ceram & Superfine, Shanghai Inst Ceram, 1295 Dingxi Rd, Shanghai 200050, Peoples R China

[2] Univ Chinese Acad Sci, Ctr Mat Sci & Optoelect Engn, 19 Yuquan Rd, Beijing 100049, Peoples R China

[3] Shanghai Jiao Tong Univ, Sch Pharm, 800 Dongchuan Rd, Shanghai 200240, Peoples R China

来源：

NPG ASIA MATERIALS | 2019年 / 11卷 / 1期

关键词：

POLY(L-GLUTAMIC ACID); INJECTABLE HYDROGELS; CROSS-LINKING; TISSUE; ANTIBACTERIAL; HEMOSTASIS; CHEMISTRY; MEDICINE; ALGINATE; CELLS;

D O I：

10.1038/s41427-019-0168-0

中图分类号：

T [工业技术];

学科分类号：

120111 [工业工程];

摘要：

Dual adhesiveness to tissue and implant biomaterials and bioactivity to stimulate tissue regeneration are interesting properties for developing new generations of tissue-repairing hydrogels with potential new clinical applications. In this study, we developed a unique bioglass (BG)/oxidized sodium alginate (OSA) composite hydrogel with adipic acid dihydrazide (ADH)-modified y-polyglutamic acid (y-PGA) as the cross-linking agent, in which the BG plays a multifunctional role to endow the hydrogel with both dual-adhesive and bioactive properties. On one hand, the BG could improve the tissue-bonding strength by providing an alkaline microenvironment to stimulate the bond formation between OSA and the amino groups on the surrounding tissues. On the other hand, BG endows the hydrogel with adhesiveness to implantable materials by releasing Ca ions, which might chelate with the carboxyl groups of the hydrogel matrix. In addition, the composite hydrogel showed excellent bioactivity to promote vascularization and accelerate tissue regeneration. This study demonstrates that a multifunctional hydrogel can be designed by utilizing the multifunctional ions released from silicate BG, and the BG/OSA hydrogel shows good potential as an adhesive and bioactive material for wound-healing applications.

引用

页数：11

共 39 条

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