An astrocyte bridge from synapse to blood flow

被引：54

作者：

Parri, R ^{[1
]}

Crunelli, V ^{[1
]}

机构：

[1] Cardiff Univ, Sch Biosci, Cardiff CF10 3US, S Glam, Wales

来源：

NATURE NEUROSCIENCE | 2003年 / 6卷 / 01期

关键词：

D O I：

10.1038/nn0103-5

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Neural activity locally Increases cerebral blood flow to deliver oxygen to working neurons. A new paper shows that astrocytes can detect activity at glutamatergic synapses via calcium changes In astrocytic endfeet and directly couple It to blood flow in vitro and In vivo.

引用

页码：5 / 6

页数：2

共 15 条

[1] Prostaglandins stimulate calcium-dependent glutamate release in astrocytes [J].

Bezzi, P ;

Carmignoto, G ;

Pasti, L ;

Vesce, S ;

Rossi, D ;

Rizzini, BL ;

Pozzan, T ;

Volterra, A .

NATURE, 1998, 391 (6664) :281-285

[2] Does glutamate image your thoughts? [J].

Bonvento, G ;

Sibson, N ;

Pellerin, L .

TRENDS IN NEUROSCIENCES, 2002, 25 (07) :359-364

[3] EDHF:: bringing the concepts together [J].

Busse, R ;

Edwards, G ;

Félétou, M ;

Fleming, I ;

Vanhoutte, PM ;

Weston, AH .

TRENDS IN PHARMACOLOGICAL SCIENCES, 2002, 23 (08) :374-380

[4] Regulation of the cerebral circulation: Role of endothelium and potassium channels [J].

Faraci, FM ;

Heistad, DD .

PHYSIOLOGICAL REVIEWS, 1998, 78 (01) :53-97

[5] Glia: Listening and talking to the synapse [J].

Haydon, PG .

NATURE REVIEWS NEUROSCIENCE, 2001, 2 (03) :185-193

[6] Dopaminergic regulation of cerebral cortical microcirculation [J].

Krimer, LS ;

Muly, EC ;

Williams, GV ;

Goldman-Rakic, PS .

NATURE NEUROSCIENCE, 1998, 1 (04) :286-289

[7]

LADECOLA C, 1993, TRENDS NEUROSCI, V16, P206

[8] Neurophysiological investigation of the basis of the fMRI signal [J].

Logothetis, NK ;

Pauls, J ;

Augath, M ;

Trinath, T ;

Oeltermann, A .

NATURE, 2001, 412 (6843) :150-157

[9] GLUTAMATE UPTAKE INTO ASTROCYTES STIMULATES AEROBIC GLYCOLYSIS - A MECHANISM COUPLING NEURONAL-ACTIVITY TO GLUCOSE-UTILIZATION [J].

PELLERIN, L ;

MAGISTRETTI, PJ .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1994, 91 (22) :10625-10629

[10] Behind the scenes of functional brain imaging: A historical and physiological perspective [J].

Raichle, ME .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1998, 95 (03) :765-772

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