Efficient synthesis of neomycin B related aminoglycosides

被引：23

作者：

Ding, YL ^{[1
]}

Swayze, EE ^{[1
]}

Hofstadler, SA ^{[1
]}

Griffey, RH ^{[1
]}

机构：

[1] ISIS Pharmaceut, Div A, Ibis Therapeut, Carlsbad, CA 92008 USA

来源：

TETRAHEDRON LETTERS | 2000年 / 41卷 / 21期

关键词：

aminoglycosides; neomycin B derivatives; synthesis;

D O I：

10.1016/S0040-4039(00)00586-4

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Aminoglycosides 6'-hydroxyl-ribostamycin and 5-(alpha-neobiosamine)-2-deoxystreptamine were chemically synthesized. These compounds will be used as standards to compare RNA binding affinity and specificity with neomycin B. (C) 2000 Elsevier Science Ltd. All rights reserved.

引用

页码：4049 / 4052

页数：4

共 13 条

[1] Metal catalyzed diazo transfer for the synthesis of azides from amines [J].

Alper, PB ;

Hung, SC ;

Wong, CH .

TETRAHEDRON LETTERS, 1996, 37 (34) :6029-6032

[2] RNA as a small-molecule drug target: doubling the value of genomics [J].

Ecker, DJ ;

Griffey, RH .

DRUG DISCOVERY TODAY, 1999, 4 (09) :420-429

[3]

Green MR, 1993, AIDS RES REV, V3, P41

[4] AMINOGLYCOSIDE ANTIBIOTICS - CHEMICAL CONVERSION OF NEOMYCIN-B, PAROMOMYCIN, AND LIVIDOMYCIN-B INTO BIOACTIVE PSEUDOSACCHARIDES [J].

HANESSIAN, S ;

TAKAMOTO, T ;

MASSE, R ;

PATIL, G .

CANADIAN JOURNAL OF CHEMISTRY-REVUE CANADIENNE DE CHIMIE, 1978, 56 (11) :1482-1491

[5] AMINOGLYCOSIDE ANTIBIOTICS - FORMATION AND CHARACTERIZATION OF DIHYDROOXAZINE DERIVATIVES IN PAROMOMYCIN SERIES [J].

HANESSIAN, S ;

MASSE, R ;

EKBORG, G .

CANADIAN JOURNAL OF CHEMISTRY-REVUE CANADIENNE DE CHIMIE, 1978, 56 (11) :1492-1499

[6]

HUCHENRAUCH R, 1967, PRARM Z DTSCHI, V106, P665

[7]

Koeda T., 1982, AMINOGLYCOSIDE ANTIB, P293

[8] AMINOGLYCOSIDE ANTIBIOTICS .4. REGIOSPECIFIC PARTIAL SYNTHESIS OF RIBOSTAMYCIN AND 4''-THIORIBOSTAMYCIN [J].

KUMAR, V ;

REMERS, WA .

JOURNAL OF ORGANIC CHEMISTRY, 1981, 46 (21) :4298-4300

[9]

RINEHART KL, 1964, NEOMYCINS RELATED AN, P93

[10]

STAGE TK, 1995, RNA, V1, P95

← 1 2 →