Strategies to restore motor functions after spinal cord injury

被引：75

作者：

Boulenguez, Pascale

Vinay, Laurent ^{[1
]}

机构：

[1] CNRS, Lab Plasticite & Physiopathol Motricite, UMR6196, F-13402 Marseille 20, France

来源：

CURRENT OPINION IN NEUROBIOLOGY | 2009年 / 19卷 / 06期

关键词：

CENTRAL-NERVOUS-SYSTEM; OLFACTORY ENSHEATHING CELLS; CENTRAL PATTERN GENERATOR; PROMOTES AXONAL REGENERATION; INDUCED HINDLIMB MOVEMENTS; MARROW STROMAL CELLS; A ANTIBODY TREATMENT; LOCOMOTOR RECOVERY; STEM-CELLS; IN-VITRO;

D O I：

10.1016/j.conb.2009.10.005

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

This review presents recent advances in the development of strategies to restore posture and locomotion after spinal cord injury (SCI). A set of strategies focusing on the lesion site includes prevention of secondary damages, promotion of axonal sprouting/regeneration, and replacement of lost cells. Other strategies focus on spinal central pattern generators (CPGs). Training promotes functional recovery by enhancing the plasticity of CPGs and these sublesional networks can be reactivated by means of pharmacological or electrical stimulation. It is now clear that substantial functional recovery will require a combination of strategies adapted to each phase following SCI. Finally, improvements in the understanding of the mechanisms underlying spasticity may lead to new treatments of this disabling complication affecting patients with SCI.

引用

收藏

页码：587 / 600

页数：14

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