Swelling and diffusion characteristics of modified poly (N-isopropylacrylamide) hydrogels

被引：42

作者：

Fu, G.

Soboyejo, W. O. ^{[1
]}

机构：

[1] Princeton Inst Sci & Technol Mat PRISM, Princeton, NJ 08544 USA

来源：

MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS | 2010年 / 30卷 / 01期

关键词：

Poly (N-isopropylacrylamide); Thermo-responsive hydrogel; Diffusion; Swelling; Trypan blue; Drug delivery; STIMULI-RESPONSIVE POLYMERS; DRUG-DELIVERY SYSTEMS; NETWORK HYDROGELS; BIOMEDICAL APPLICATIONS; SENSITIVE POLYMERS; TEMPERATURE; RELEASE; POLY(N-ISOPROPYLACRYLAMIDE); ALGINATE; ACRYLAMIDE);

D O I：

10.1016/j.msec.2009.07.017

中图分类号：

TB3 [工程材料学]; R318.08 [生物材料学];

学科分类号：

082905 [生物质能源与材料]; 100103 [病原生物学];

摘要：

Thermo-responsive hydrogels are capable of swelling changes to external temperature. A series of modified poly (N-isopropylacrylamide) (PNIPA) hydrogels was synthesized by free radical polymerization in aqueous solution. Acrylamide (AAm) was used to increase the lower critical solution temperature (LCST). while sodium alginate (SA) was used to improve the swelling performance of the hydrogels. Experiments show that 5.5% mass ratio of AAm increased the LCST by about 9 degrees C above that of conventional PNIPA. Also, SA significantly improved the equilibrium swelling ratio associate with temperature change. Trypan blue diffusion revealed significant differences in the fluid release obtained from hydrogels with modified LCST and swelling properties. The implications of the modified fluid release and swelling characteristics are also discussed for the device design of thermo-sensitive hydrogels for localized drug delivery. (C) 2009 Published by Elsevier B.V.

引用

页码：8 / 13

页数：6

共 37 条

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