Synaptic tagging - Who's it?

被引：160

作者：

Martin, KC

Kosik, KS

机构：

[1] Univ Calif Los Angeles, Brain Res Inst, Dept Psychiat & Biobehav Sci, Los Angeles, CA 90095 USA

[2] Univ Calif Los Angeles, Brain Res Inst, Dept Biol Chem, Los Angeles, CA 90095 USA

[3] Brigham & Womens Hosp, Dept Neurol, Boston, MA 02115 USA

[4] Harvard Univ, Sch Med, Harvard Inst Med, Boston, MA 02115 USA

来源：

NATURE REVIEWS NEUROSCIENCE | 2002年 / 3卷 / 10期

关键词：

D O I：

10.1038/nrn942

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

A synaptic tag transiently marks a synapse after activation in a way that allows the local recognition of transcriptional products to effect an enduring change in transmission efficiency. The idea of the synaptic tag as a single molecule might be misguided; instead, a process such as activation of local translation or cytoskeletal reorganization could mark a synapse. A change of this nature might be modulated directly or indirectly by transcriptional products that, for example, modulate translational activity, mRNA stability or protein degradation, or are ensconced in a cytoskeletal configuration, and thereby lead to long-term changes in synaptic strength.

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收藏

页码：813 / 820

页数：8

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