Jun in Drosophila development: Redundant and nonredundant functions and regulation by two MAPK signal transduction pathways

被引：127

作者：

Kockel, L ^{[1
]}

Zeitlinger, J ^{[1
]}

Staszewski, LM ^{[1
]}

Mlodzik, M ^{[1
]}

Bohmann, D ^{[1
]}

机构：

[1] EUROPEAN MOL BIOL LAB,D-69117 HEIDELBERG,GERMANY

来源：

GENES & DEVELOPMENT | 1997年 / 11卷 / 13期

关键词：

Drosophila development; Jun; JNK; ERK; signal transduction; transcription factor;

D O I：

10.1101/gad.11.13.1748

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Drosophila Jun is shown to be involved in different signal transduction pathways and developmental decisions. Dorsal closure, a morphogenetic process occurring during Drosophila embryogenesis, is regulated by Hemipterous (Hep) and Basket (Bsk), homologs of JNKK and JNK, respectively. Embryos lacking Jun activity exhibit a dorsal closure phenotype, very similar to that of bsk and hep mutants, indicating that Jun is a target of Hep/Bsk signaling. In eye and wing development Jun participates in a separate signaling pathway that is comprised of Ras, Raf, and the ERK-type kinase Rolled. In contrast to the strict requirement for Jun in dorsal closure, its role in the eye is redundant but can be uncovered by mutations in other signaling components. The redundant function of Jun in eye development may contribute to the precision of photoreceptor differentiation and ommatidial assembly.

引用

页码：1748 / 1758

页数：11

共 55 条

[1] THE ROLE OF JUN, FOS AND THE AP-1 COMPLEX IN CELL-PROLIFERATION AND TRANSFORMATION [J].