Fungicidal Action of Hydroxyl Radicals Generated by Ultrasound in Water

被引：21

作者：

Iwasawa, Atsuo ^{[1
,2
]}

Saito, Keita ^{[2
]}

Mokudai, Takayuki ^{[2
]}

Kohno, Masahiro ^{[2
]}

Ozawa, Toshihiko ^{[2
,3
]}

Niwano, Yoshimi ^{[2
]}

机构：

[1] Showa Univ, Fujigaoka Hosp, Tissue Culture Lab, Aoba Ku, Kanagawa 2278501, Japan

[2] Tohoku Univ, New Ind Creat Hatchery Ctr, Aoba Ku, Sendai, Miyagi 9808579, Japan

[3] Yokohama Coll Pharm, Dept Hlth Pharm, Toduka Ku, Kanagawa 2450066, Japan

来源：

JOURNAL OF CLINICAL BIOCHEMISTRY AND NUTRITION | 2009年 / 45卷 / 02期

关键词：

ultrasound; hydroxyl radical; Trichophyton spp; fungicidal activity; electron microscopy; ITRACONAZOLE TREATMENT; ONYCHOMYCOSIS; MACROPHAGES; TERBINAFINE; THERAPY; STRAINS; PULSE;

D O I：

10.3164/jcbn.08-261

中图分类号：

R15 [营养卫生、食品卫生]; TS201 [基础科学];

学科分类号：

100403 [营养与食品卫生学];

摘要：

It is well known that hydroxyl radicals are generated by ultrasound in water. This study with an electron spin resonance spin-trapping technique showed that hydroxyl radical generation was positively correlated with ultrasound duration and water temperature. The clear fungicidal action against Trichophyton spp. evident by studying cultured cells and the degradation of cytoplasmic and surface structures observed by transmission and scanning electron microscopy suggest that ultrasound in hot water is effective for sterilization of dermatophyte contamination and could be effective for the treatment of tinea infection.

引用

页码：214 / 218

页数：5

共 22 条

[1]

BORGERS M, 1987, REV INFECT DIS, V9, pS33

[2]

A comparison among four regimens of itraconazole treatment in onychomycosis [J].

Chen, J ;

Liao, W ;

Wen, H ;

Wu, J ;

Yao, Z .

MYCOSES, 1999, 42 (1-2) :93-96

[3]

DEDONCKER P, 1995, CUTIS, V56, P180

[4]

KILLING OF HISTOPLASMA-CAPSULATUM BY MACROPHAGE-COLONY-STIMULATING FACTOR-TREATED HUMAN MONOCYTE-DERIVED MACROPHAGES - ROLE FOR REACTIVE OXYGEN INTERMEDIATES [J].

DESAI, G ;

NASSAR, F ;

BRUMMER, E ;

STEVENS, DA .

JOURNAL OF MEDICAL MICROBIOLOGY, 1995, 43 (03) :224-229

[5]

MECHANISMS OF CELL INJURY BY ACTIVATED OXYGEN SPECIES [J].

FARBER, JL .

ENVIRONMENTAL HEALTH PERSPECTIVES, 1994, 102 :17-24

[6]

SHORT-DURATION THERAPY WITH TERBINAFINE FOR DERMATOPHYTE ONYCHOMYCOSIS - A MULTICENTER TRIAL [J].

GOODFIELD, MJD .

BRITISH JOURNAL OF DERMATOLOGY, 1992, 126 :33-35

[7]

Measurement of hydroxyl radical production in ultrasonic aqueous solutions by a novel chemiluminescence method [J].

Hu, Yufei ;

Zhang, Zhujun ;

Yang, Chunyan .

ULTRASONICS SONOCHEMISTRY, 2008, 15 (05) :665-672

[8]

Javier Mendez-Tovar Luis, 2007, Revista Iberoamericana de Micologia, V24, P320

[9]

INVOLVEMENT OF REACTIVE OXYGEN METABOLITES IN THE CANDIDACIDAL ACTIVITY OF HUMAN-NEUTROPHILS STIMULATED BY MURAMYL DIPEPTIDE OR TUMOR NECROSIS FACTOR [J].

JUPIN, C ;

PARANT, M ;

CHEDID, L .

IMMUNOBIOLOGY, 1989, 180 (01) :68-79

[10]

Comparative toxicities of putative phagocyte-generated oxidizing radicals toward a bacterium (Escherichia coli) and a yeast (Saccharomyces cerevisiae) [J].

King, David A. ;

Sheafor, Mark W. ;

Hurst, James K. .

FREE RADICAL BIOLOGY AND MEDICINE, 2006, 41 (05) :765-774

← 1 2 3 →