Hepatitis C virus versus innate and adaptive immune responses: a tale of coevolution and coexistence

被引：415

作者：

Rehermann, Barbara ^{[1
]}

机构：

[1] NIDDK, Immunol Sect, Liver Dis Branch, NIH,US Dept HHS, Bethesda, MD 20892 USA

来源：

JOURNAL OF CLINICAL INVESTIGATION | 2009年 / 119卷 / 07期

关键词：

CD8(+) T-CELLS; SINGLE-SOURCE OUTBREAK; ACUTE HCV INFECTION; PERIPHERAL-BLOOD; PD-1; EXPRESSION; DENDRITIC CELLS; NEUTRALIZING ANTIBODY; VIRAL CLEARANCE; CORE PROTEIN; NONSTRUCTURAL PROTEIN-3;

D O I：

10.1172/JCI39133

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Since the identification of the hepatitis C virus (HCV) 20 years ago, much progress has been made in our understanding of its life cycle and interaction with the host immune system. Much has been learned from HCV itself, which, via decades of coevolution, gained an intricate knowledge of host innate and adaptive immune responses and developed sophisticated ways to preempt, subvert, and antagonize them. This review discusses the clinical, virological, and immunological features of acute and chronic hepatitis C and the role of the immune response in spontaneous and treatment-induced HCV clearance.

引用

页码：1745 / 1754

页数：10

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