Effects of teriparatide and alendronate on vertebral strength as assessed by finite element modeling of QCT scans in women with osteoporosis

被引：171

作者：

Keaveny, Tony M. ^{[1
]}

Donley, David W.

Hoffmann, Paul F.

Mitlak, Bruce H.

Glass, Emmett V.

San Martin, Javier A.

机构：

[1] Univ Calif Berkeley, Berkeley, CA 94720 USA

[2] ON Diagnost, Berkeley, CA USA

[3] Eli Lilly & Co, Indianapolis, IN 46285 USA

来源：

JOURNAL OF BONE AND MINERAL RESEARCH | 2007年 / 22卷 / 01期

关键词：

finite element analysis; teriparatide; PTH(1-34); alendronate; bone strength; bone quality;

D O I：

10.1359/JBMR.061011

中图分类号：

R5 [内科学];

学科分类号：

1002 [临床医学]; 100201 [内科学];

摘要：

FE modeling was used to estimate the biomechanical effects of teriparatide and alendronate on lumbar vertebrae. Both treatments enhanced predicted vertebral strength by increasing average density. This effect was more pronounced for teriparatide, which further increased predicted vertebral strength by altering the distribution of density within the vertebra, preferentially increasing the strength of the trabecular compartment.

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收藏

页码：149 / 157

页数：9

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