Microwave-assisted synthesis of sodium sulfonates precursors of sulfonyl chlorides and fluorides

被引：14

作者：

Alapafuja, Shakiru O. ^{[1
]}

Nikas, Spyros P. ^{[1
]}

Shukla, Vidyanand G. ^{[1
]}

Papanastasiou, Ioannis ^{[1
]}

Makriyannis, Alexandros ^{[1
]}

机构：

[1] Northeastern Univ, Ctr Drug Discovery, Boston, MA 02115 USA

来源：

TETRAHEDRON LETTERS | 2009年 / 50卷 / 50期

关键词：

Sodium sulfonates; Microwave; Sulfonyl chlorides; Sulfonyl fluorides; ACID AMIDE HYDROLASE; MOLECULAR CHARACTERIZATION; ENDOCANNABINOID SYSTEM; FACILE SYNTHESIS; DERIVATIVES; ANANDAMIDE; THIOLS; ENZYME;

D O I：

10.1016/j.tetlet.2009.09.167

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

We describe the use of a microwave reaction for the conversion of various bromides to sodium sulfonates that have been further elaborated to sulfonyl chlorides. This new approach leads to much improved yields and shorter reaction times. Representative sulfonyl chlorides serve as precursors for the respective sulfonyl fluorides that are potent inhibitors of the fatty acid amide hydrolase. (C) 2009 Elsevier Ltd. All rights reserved.

引用

页码：7028 / 7031

页数：4

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