Biological and biomedical implications of the co-evolution of pathogens and their hosts

被引:600
作者
Woolhouse, MEJ
Webster, JP
Domingo, E
Charlesworth, B
Levin, BR
机构
[1] Univ Edinburgh, Coll Med & Vet Med, Ctr Infect Dis, Roslin EH25 9RG, Midlothian, Scotland
[2] Univ Autonoma Madrid, Ctr Biol Mol, E-28049 Madrid, Spain
[3] Univ Oxford, Oxford, England
[4] Dept Zool, Oxford OX1 3PS, England
[5] Univ Edinburgh, Inst Cell Anim & Populat Biol, Edinburgh, Midlothian, Scotland
[6] Emory Univ, Dept Biol, Atlanta, GA 30322 USA
关键词
D O I
10.1038/ng1202-569
中图分类号
Q3 [遗传学];
学科分类号
071007 ; 090102 ;
摘要
Co-evolution between host and pathogen is, in principle, a powerful determinant of the biology and genetics of infection and disease. Yet co-evolution has proven difficult to demonstrate rigorously in practice, and co-evolutionary thinking is only just beginning to inform medical or veterinary research in any meaningful way, even though it can have a major influence on how genetic variation in biomedically important traits is interpreted. Improving our understanding of the biomedical significance of co-evolution will require changing the way in which we look for it, complementing the phenomenological approach traditionally favored by evolutionary biologists with the exploitation of the extensive data becoming available on the molecular biology and molecular genetics of host-pathogen interactions.
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收藏
页码:569 / 577
页数:9
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