Immunotherapy to reconstitute immunity to DNA viruses

被引：9

作者：

Gahn, B ^{[1
]}

Hunt, G ^{[1
]}

Rooney, CM ^{[1
]}

Heslop, HE ^{[1
]}

机构：

[1] Baylor Coll Med, Ctr Cell & Gene Therapy, Houston, TX 77030 USA

来源：

SEMINARS IN HEMATOLOGY | 2002年 / 39卷 / 01期

关键词：

D O I：

10.1053/shem.2002.29252

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Defects in cytotoxic T-lymphocyte (CTL) function after hemopoietic stem cell transplantation (HSCT) are associated with an increased frequency and severity of viral diseases. Initial investigations of viral infections in immunosuppressed mice and subsequent clinical studies of cytomegalovirus (CMV) and Epstein-Barr virus (EBV) in human stem cell transplant patients have suggested that adoptive transfer of virus-specific T cells may restore protective immunity and control established infections. Current efforts focus on optimizing adoptive immunotherapy approaches and developing strategies for generating T cells specific for multiple viruses to provide broader protection. Copyright © 2002 by W.B. Saunders Company.

引用

页码：41 / 47

页数：7

共 68 条

[1]

[Anonymous], 1996, Fields virology

[2]

Bollard CM, 2000, BLOOD, V96, p478A

[3] HSV-TK gene transfer into donor lymphocytes for control of allogeneic graft-versus-leukemia [J].

Bonini, C ;

Ferrari, G ;

Verzeletti, S ;

Servida, P ;

Zappone, E ;

Ruggieri, L ;

Ponzoni, M ;

Rossini, S ;

Mavilio, F ;

Traversari, C ;

Bordignon, C .

SCIENCE, 1997, 276 (5319) :1719-1724

[4] Recognition of human cytomegalovirus gene products by HCMV-specific cytotoxic T cells [J].

Boppana, SB ;

Britt, WJ .

VIROLOGY, 1996, 222 (01) :293-296

[5] UNRELATED BONE-MARROW DONOR TRANSPLANTS FOR CHILDREN WITH LEUKEMIA OR MYELODYSPLASIA [J].

CASPER, J ;

CAMITTA, B ;

TRUITT, R ;

BAXTERLOWE, LA ;

BUNIN, N ;

LAWTON, C ;

MURRAY, K ;

HUNTER, J ;

PIETRYGA, D ;

GARBRECHT, F ;

KEEVER, C ;

DROBYSKI, W ;

HOROWITZ, M ;

FLOMENBERG, N ;

ASH, R .

BLOOD, 1995, 85 (09) :2354-2363

[6]

Cavazzana-Calvo M, 1998, BRIT J HAEMATOL, V103, P543

[7]

Cavazzana-Calvo M, 2001, BONE MARROW TRANSPL, V27, pS128

[8]

Curtis RE, 1999, BLOOD, V94, P2208

[9] Direct visualization of cytomegalovirus-specific T-cell reconstitution after allogeneic stem cell transplantation [J].

Cwynarski, K ;

Ainsworth, J ;

Cobbold, M ;

Wagner, S ;

Mahendra, P ;

Apperley, J ;

Goldman, J ;

Craddock, C ;

Moss, PAH .

BLOOD, 2001, 97 (05) :1232-1240

[10] Characterization of CMVpp65-specific CD8+T lymphocytes using MHC tetramers in kidney transplant patients and healthy participants [J].

Engstrand, M ;

Tournay, C ;

Peyrat, MA ;

Eriksson, BM ;

Wadström, J ;

Wirgart, BZ ;

Romagné, F ;

Bonneville, M ;

Tötterman, TH ;

Korsgren, O .

TRANSPLANTATION, 2000, 69 (11) :2243-2250

← 1 2 3 4 5 6 7 →